TY - JOUR
T1 - Radiofrequency ablation of premature ventricular ectopy improves the efficacy of cardiac resynchronization therapy in nonresponders
AU - Lakkireddy, Dhanunjaya
AU - Di Biase, Luigi
AU - Ryschon, Kay
AU - Biria, Mazda
AU - Swarup, Vijay
AU - Reddy, Yeruva Madhu
AU - Verma, Atul
AU - Bommana, Sudharani
AU - Burkhardt, David
AU - Dendi, Raghuveer
AU - Dello Russo, Antonio
AU - Casella, Michela
AU - Carbucicchio, Corrado
AU - Tondo, Claudio
AU - Dawn, Buddhadeb
AU - Natale, Andrea
N1 - Funding Information:
Dr. Lakkireddy has received modest speaker/consulting honoraria from St. Jude Medical, Boehringer Ingelheim, and Jansen. Dr. Di Biase is a consultant for Hansen Medical and Biosense Webster. Dr. Verma has received research grants from Medtronic and St. Jude Medical . Dr. Burkhardt a consultant for Stereotaxis and Biosense Webster. Dr. Tondo is a member of the advisory boards of Biosense Webster and Biotronik; and has received lecture fees from St. Jude Medical. Dr. Natale has received speaker honoraria from Boston Scientific, Biosense Webster, St. Jude Medical, Biotronik, and Life Watch. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Drs. Lakkireddy and Di Biase contributed equally to this work and both should be considered as co-first authors.
PY - 2012/10/16
Y1 - 2012/10/16
N2 - Objectives: This study sought to examine whether suppressing premature ventricular contractions (PVC) using radiofrequency ablation improves effectiveness of the cardiac resynchronization therapy (CRT) in nonresponders. Background: CRT is an effective strategy for drug refractory congestive heart failure. However, one-third of patients with CRT do not respond clinically, and the causes for nonresponse are poorly understood. Whether frequent PVC contribute to CRT nonresponse remains unknown. Methods: In this multicenter study, CRT nonresponders with >10,000 PVC in 24 h who underwent PVC ablation were enrolled from a prospective database. Results: Sixty-five subjects (age 66.6 ± 12.4 years, 78% men, QRS duration of 155 ± 18 ms) had radiofrequency ablation of PVC from 76 foci. Acute and long-term success rates of ablation were 91% and 88% in 12 ± 4 months of follow-up. There was significant improvement in left ventricular (LV) ejection fraction (26.2 ± 5.5% to 32.7 ± 6.7 %, p < 0.001), LV end-systolic diameter (5.93 ± 0.55 cm to 5.62 ± 0.32 cm, p < 0.001), LV end-diastolic diameter (6.83 ± 0.83 cm to 6.51 ± 0.91 cm, p < 0.001), LV end-systolic volume (178 ± 72 to 145 ± 23 ml, p < 0.001), LV end-diastolic volume (242 ± 85 ml to 212 ± 63 ml, p < 0.001), and median New York Heart Association functional class (3.0 to 2.0, p < 0.001). Modeling of pre-ablation PVC burden revealed an improvement in ejection fraction when the pre-ablation PVC burden was >22% in 24 h. Conclusions: Frequent PVC is an uncommon yet significant cause of CRT nonresponse. Radiofrequency ablation of PVC foci improves LV function and New York Heart Association class and promotes reverse remodeling in CRT nonresponders. PVC ablation may be used to enhance CRT efficacy in nonresponders with significant PVC burden.
AB - Objectives: This study sought to examine whether suppressing premature ventricular contractions (PVC) using radiofrequency ablation improves effectiveness of the cardiac resynchronization therapy (CRT) in nonresponders. Background: CRT is an effective strategy for drug refractory congestive heart failure. However, one-third of patients with CRT do not respond clinically, and the causes for nonresponse are poorly understood. Whether frequent PVC contribute to CRT nonresponse remains unknown. Methods: In this multicenter study, CRT nonresponders with >10,000 PVC in 24 h who underwent PVC ablation were enrolled from a prospective database. Results: Sixty-five subjects (age 66.6 ± 12.4 years, 78% men, QRS duration of 155 ± 18 ms) had radiofrequency ablation of PVC from 76 foci. Acute and long-term success rates of ablation were 91% and 88% in 12 ± 4 months of follow-up. There was significant improvement in left ventricular (LV) ejection fraction (26.2 ± 5.5% to 32.7 ± 6.7 %, p < 0.001), LV end-systolic diameter (5.93 ± 0.55 cm to 5.62 ± 0.32 cm, p < 0.001), LV end-diastolic diameter (6.83 ± 0.83 cm to 6.51 ± 0.91 cm, p < 0.001), LV end-systolic volume (178 ± 72 to 145 ± 23 ml, p < 0.001), LV end-diastolic volume (242 ± 85 ml to 212 ± 63 ml, p < 0.001), and median New York Heart Association functional class (3.0 to 2.0, p < 0.001). Modeling of pre-ablation PVC burden revealed an improvement in ejection fraction when the pre-ablation PVC burden was >22% in 24 h. Conclusions: Frequent PVC is an uncommon yet significant cause of CRT nonresponse. Radiofrequency ablation of PVC foci improves LV function and New York Heart Association class and promotes reverse remodeling in CRT nonresponders. PVC ablation may be used to enhance CRT efficacy in nonresponders with significant PVC burden.
KW - cardiac resynchronization therapy
KW - premature ventricular contraction
KW - radiofrequency ablation
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U2 - 10.1016/j.jacc.2012.06.035
DO - 10.1016/j.jacc.2012.06.035
M3 - Article
C2 - 22999718
AN - SCOPUS:84867397463
SN - 0735-1097
VL - 60
SP - 1531
EP - 1539
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 16
ER -