Radiofrequency ablation of premature ventricular ectopy improves the efficacy of cardiac resynchronization therapy in nonresponders

Dhanunjaya Lakkireddy, Luigi Di Biase, Kay Ryschon, Mazda Biria, Vijay Swarup, Yeruva Madhu Reddy, Atul Verma, Sudharani Bommana, David Burkhardt, Raghuveer Dendi, Antonio Dello Russo, Michela Casella, Corrado Carbucicchio, Claudio Tondo, Buddhadeb Dawn, Andrea Natale

Research output: Contribution to journalArticle

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Abstract

Objectives: This study sought to examine whether suppressing premature ventricular contractions (PVC) using radiofrequency ablation improves effectiveness of the cardiac resynchronization therapy (CRT) in nonresponders. Background: CRT is an effective strategy for drug refractory congestive heart failure. However, one-third of patients with CRT do not respond clinically, and the causes for nonresponse are poorly understood. Whether frequent PVC contribute to CRT nonresponse remains unknown. Methods: In this multicenter study, CRT nonresponders with >10,000 PVC in 24 h who underwent PVC ablation were enrolled from a prospective database. Results: Sixty-five subjects (age 66.6 ± 12.4 years, 78% men, QRS duration of 155 ± 18 ms) had radiofrequency ablation of PVC from 76 foci. Acute and long-term success rates of ablation were 91% and 88% in 12 ± 4 months of follow-up. There was significant improvement in left ventricular (LV) ejection fraction (26.2 ± 5.5% to 32.7 ± 6.7 %, p < 0.001), LV end-systolic diameter (5.93 ± 0.55 cm to 5.62 ± 0.32 cm, p < 0.001), LV end-diastolic diameter (6.83 ± 0.83 cm to 6.51 ± 0.91 cm, p < 0.001), LV end-systolic volume (178 ± 72 to 145 ± 23 ml, p < 0.001), LV end-diastolic volume (242 ± 85 ml to 212 ± 63 ml, p < 0.001), and median New York Heart Association functional class (3.0 to 2.0, p < 0.001). Modeling of pre-ablation PVC burden revealed an improvement in ejection fraction when the pre-ablation PVC burden was >22% in 24 h. Conclusions: Frequent PVC is an uncommon yet significant cause of CRT nonresponse. Radiofrequency ablation of PVC foci improves LV function and New York Heart Association class and promotes reverse remodeling in CRT nonresponders. PVC ablation may be used to enhance CRT efficacy in nonresponders with significant PVC burden.

Original languageEnglish (US)
Pages (from-to)1531-1539
Number of pages9
JournalJournal of the American College of Cardiology
Volume60
Issue number16
DOIs
StatePublished - Oct 16 2012
Externally publishedYes

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Cardiac Resynchronization Therapy
Ventricular Premature Complexes
Left Ventricular Function
Stroke Volume
Multicenter Studies
Heart Failure
Databases

Keywords

  • cardiac resynchronization therapy
  • premature ventricular contraction
  • radiofrequency ablation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Radiofrequency ablation of premature ventricular ectopy improves the efficacy of cardiac resynchronization therapy in nonresponders. / Lakkireddy, Dhanunjaya; Di Biase, Luigi; Ryschon, Kay; Biria, Mazda; Swarup, Vijay; Reddy, Yeruva Madhu; Verma, Atul; Bommana, Sudharani; Burkhardt, David; Dendi, Raghuveer; Dello Russo, Antonio; Casella, Michela; Carbucicchio, Corrado; Tondo, Claudio; Dawn, Buddhadeb; Natale, Andrea.

In: Journal of the American College of Cardiology, Vol. 60, No. 16, 16.10.2012, p. 1531-1539.

Research output: Contribution to journalArticle

Lakkireddy, D, Di Biase, L, Ryschon, K, Biria, M, Swarup, V, Reddy, YM, Verma, A, Bommana, S, Burkhardt, D, Dendi, R, Dello Russo, A, Casella, M, Carbucicchio, C, Tondo, C, Dawn, B & Natale, A 2012, 'Radiofrequency ablation of premature ventricular ectopy improves the efficacy of cardiac resynchronization therapy in nonresponders', Journal of the American College of Cardiology, vol. 60, no. 16, pp. 1531-1539. https://doi.org/10.1016/j.jacc.2012.06.035
Lakkireddy, Dhanunjaya ; Di Biase, Luigi ; Ryschon, Kay ; Biria, Mazda ; Swarup, Vijay ; Reddy, Yeruva Madhu ; Verma, Atul ; Bommana, Sudharani ; Burkhardt, David ; Dendi, Raghuveer ; Dello Russo, Antonio ; Casella, Michela ; Carbucicchio, Corrado ; Tondo, Claudio ; Dawn, Buddhadeb ; Natale, Andrea. / Radiofrequency ablation of premature ventricular ectopy improves the efficacy of cardiac resynchronization therapy in nonresponders. In: Journal of the American College of Cardiology. 2012 ; Vol. 60, No. 16. pp. 1531-1539.
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abstract = "Objectives: This study sought to examine whether suppressing premature ventricular contractions (PVC) using radiofrequency ablation improves effectiveness of the cardiac resynchronization therapy (CRT) in nonresponders. Background: CRT is an effective strategy for drug refractory congestive heart failure. However, one-third of patients with CRT do not respond clinically, and the causes for nonresponse are poorly understood. Whether frequent PVC contribute to CRT nonresponse remains unknown. Methods: In this multicenter study, CRT nonresponders with >10,000 PVC in 24 h who underwent PVC ablation were enrolled from a prospective database. Results: Sixty-five subjects (age 66.6 ± 12.4 years, 78{\%} men, QRS duration of 155 ± 18 ms) had radiofrequency ablation of PVC from 76 foci. Acute and long-term success rates of ablation were 91{\%} and 88{\%} in 12 ± 4 months of follow-up. There was significant improvement in left ventricular (LV) ejection fraction (26.2 ± 5.5{\%} to 32.7 ± 6.7 {\%}, p < 0.001), LV end-systolic diameter (5.93 ± 0.55 cm to 5.62 ± 0.32 cm, p < 0.001), LV end-diastolic diameter (6.83 ± 0.83 cm to 6.51 ± 0.91 cm, p < 0.001), LV end-systolic volume (178 ± 72 to 145 ± 23 ml, p < 0.001), LV end-diastolic volume (242 ± 85 ml to 212 ± 63 ml, p < 0.001), and median New York Heart Association functional class (3.0 to 2.0, p < 0.001). Modeling of pre-ablation PVC burden revealed an improvement in ejection fraction when the pre-ablation PVC burden was >22{\%} in 24 h. Conclusions: Frequent PVC is an uncommon yet significant cause of CRT nonresponse. Radiofrequency ablation of PVC foci improves LV function and New York Heart Association class and promotes reverse remodeling in CRT nonresponders. PVC ablation may be used to enhance CRT efficacy in nonresponders with significant PVC burden.",
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T1 - Radiofrequency ablation of premature ventricular ectopy improves the efficacy of cardiac resynchronization therapy in nonresponders

AU - Lakkireddy, Dhanunjaya

AU - Di Biase, Luigi

AU - Ryschon, Kay

AU - Biria, Mazda

AU - Swarup, Vijay

AU - Reddy, Yeruva Madhu

AU - Verma, Atul

AU - Bommana, Sudharani

AU - Burkhardt, David

AU - Dendi, Raghuveer

AU - Dello Russo, Antonio

AU - Casella, Michela

AU - Carbucicchio, Corrado

AU - Tondo, Claudio

AU - Dawn, Buddhadeb

AU - Natale, Andrea

PY - 2012/10/16

Y1 - 2012/10/16

N2 - Objectives: This study sought to examine whether suppressing premature ventricular contractions (PVC) using radiofrequency ablation improves effectiveness of the cardiac resynchronization therapy (CRT) in nonresponders. Background: CRT is an effective strategy for drug refractory congestive heart failure. However, one-third of patients with CRT do not respond clinically, and the causes for nonresponse are poorly understood. Whether frequent PVC contribute to CRT nonresponse remains unknown. Methods: In this multicenter study, CRT nonresponders with >10,000 PVC in 24 h who underwent PVC ablation were enrolled from a prospective database. Results: Sixty-five subjects (age 66.6 ± 12.4 years, 78% men, QRS duration of 155 ± 18 ms) had radiofrequency ablation of PVC from 76 foci. Acute and long-term success rates of ablation were 91% and 88% in 12 ± 4 months of follow-up. There was significant improvement in left ventricular (LV) ejection fraction (26.2 ± 5.5% to 32.7 ± 6.7 %, p < 0.001), LV end-systolic diameter (5.93 ± 0.55 cm to 5.62 ± 0.32 cm, p < 0.001), LV end-diastolic diameter (6.83 ± 0.83 cm to 6.51 ± 0.91 cm, p < 0.001), LV end-systolic volume (178 ± 72 to 145 ± 23 ml, p < 0.001), LV end-diastolic volume (242 ± 85 ml to 212 ± 63 ml, p < 0.001), and median New York Heart Association functional class (3.0 to 2.0, p < 0.001). Modeling of pre-ablation PVC burden revealed an improvement in ejection fraction when the pre-ablation PVC burden was >22% in 24 h. Conclusions: Frequent PVC is an uncommon yet significant cause of CRT nonresponse. Radiofrequency ablation of PVC foci improves LV function and New York Heart Association class and promotes reverse remodeling in CRT nonresponders. PVC ablation may be used to enhance CRT efficacy in nonresponders with significant PVC burden.

AB - Objectives: This study sought to examine whether suppressing premature ventricular contractions (PVC) using radiofrequency ablation improves effectiveness of the cardiac resynchronization therapy (CRT) in nonresponders. Background: CRT is an effective strategy for drug refractory congestive heart failure. However, one-third of patients with CRT do not respond clinically, and the causes for nonresponse are poorly understood. Whether frequent PVC contribute to CRT nonresponse remains unknown. Methods: In this multicenter study, CRT nonresponders with >10,000 PVC in 24 h who underwent PVC ablation were enrolled from a prospective database. Results: Sixty-five subjects (age 66.6 ± 12.4 years, 78% men, QRS duration of 155 ± 18 ms) had radiofrequency ablation of PVC from 76 foci. Acute and long-term success rates of ablation were 91% and 88% in 12 ± 4 months of follow-up. There was significant improvement in left ventricular (LV) ejection fraction (26.2 ± 5.5% to 32.7 ± 6.7 %, p < 0.001), LV end-systolic diameter (5.93 ± 0.55 cm to 5.62 ± 0.32 cm, p < 0.001), LV end-diastolic diameter (6.83 ± 0.83 cm to 6.51 ± 0.91 cm, p < 0.001), LV end-systolic volume (178 ± 72 to 145 ± 23 ml, p < 0.001), LV end-diastolic volume (242 ± 85 ml to 212 ± 63 ml, p < 0.001), and median New York Heart Association functional class (3.0 to 2.0, p < 0.001). Modeling of pre-ablation PVC burden revealed an improvement in ejection fraction when the pre-ablation PVC burden was >22% in 24 h. Conclusions: Frequent PVC is an uncommon yet significant cause of CRT nonresponse. Radiofrequency ablation of PVC foci improves LV function and New York Heart Association class and promotes reverse remodeling in CRT nonresponders. PVC ablation may be used to enhance CRT efficacy in nonresponders with significant PVC burden.

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