Radiation therapy in pancreatic cancer: Current practice and future trends

William R. Bodner, Basil S. Hilaris, Dina A. Mastoras

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Treatment options for pancreatic cancer remain limited due to the large proportion of patients presenting with advanced disease at the time of diagnosis. Surgery offers the best chance for cure. Localized chemoradiation modestly improves median survival in both localized and locally advanced disease. Interstitial brachytherapy and intraoperative radiotherapy improve local control without providing significant impact on overall survival. Technological advances now allow us to deliver three dimensional conformal external beam irradiation with improved efficacy and decreased morbidity. Novel treatment approaches, such as intraoperative photoelectron radiation (Photon Radiosurgery System(TM); PeC Photoelectron Corporation) and the development of more effective radiosensitizers, are presently under investigation.

Original languageEnglish (US)
Pages (from-to)230-233
Number of pages4
JournalJournal of clinical gastroenterology
Volume30
Issue number3
DOIs
StatePublished - Apr 1 2000

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Keywords

  • Chemoradiation
  • External beam irradiation
  • Interstitial brachytherapy
  • Intraoperative radiotherapy
  • Pancreatic neoplasms
  • Surgery
  • Three-dimensional conformal beam irradiation

ASJC Scopus subject areas

  • Gastroenterology

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