Radiation Dose-Volume Effects for Liver SBRT

Moyed Miften, Yevgeniy Vinogradskiy, Vitali Moiseenko, Jimm Grimm, Ellen Yorke, Andrew Jackson, Wolfgang A. Tomé, Randall K. Ten Haken, Nitin Ohri, Alejandra Méndez Romero, Karyn A. Goodman, Lawrence B. Marks, Brian Kavanagh, Laura A. Dawson

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Stereotactic body radiation therapy (SBRT) has emerged as an effective, noninvasive treatment option for primary liver cancer and metastatic disease occurring in the liver. Although SBRT can be highly effective for establishing local control in hepatic malignancies, a tradeoff exists between tumor control and normal tissue complications. The objective of the present study was to review the normal tissue dose-volume effects for SBRT-induced liver and gastrointestinal toxicities and derive normal tissue complication probability models.

Original languageEnglish (US)
JournalInternational Journal of Radiation Oncology Biology Physics
DOIs
StateAccepted/In press - Jan 1 2018

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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    Miften, M., Vinogradskiy, Y., Moiseenko, V., Grimm, J., Yorke, E., Jackson, A., Tomé, W. A., Ten Haken, R. K., Ohri, N., Méndez Romero, A., Goodman, K. A., Marks, L. B., Kavanagh, B., & Dawson, L. A. (Accepted/In press). Radiation Dose-Volume Effects for Liver SBRT. International Journal of Radiation Oncology Biology Physics. https://doi.org/10.1016/j.ijrobp.2017.12.290