Racial comparisons of thyroid function and autoimmunity during pregnancy and the postpartum period

Jason A. Walker, Edward H. Illions, John F. Huddleston, Robert C. Smallridge

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate thyroid function and the prevalence of thyroid peroxidase (TPO) antibody and autoimmunity in African-American and white women during pregnancy and the postpartum period. METHODS: Five hundred eighty-nine women were evaluated prospectively. Serum thyroid-stimulating hormone (TSH), free thyroxine (T4), and TPO, Ro, and La antibodies were obtained during pregnancy, at delivery, and postpartum. Levels of hCG were determined during pregnancy. Urinary iodine levels were evaluated in the third trimester in another group of women. All TPO antibody-positive patients were to be followed up at 3 and 6 months postpartum. RESULTS: African-American women had lower TSH values than white women at all times. Thyroid-stimulating hormone increased, and free T4 decreased from the first to third trimester of pregnancy for both groups. African Americans had higher hCG levels than whites in the first trimester but not in the third trimester. There was no difference in urine iodine excretion between African-American and white women. Finally, there was no difference in TPO antibody seropositivity between African-American and white women. Overall, 5 patients (0.8%) were diagnosed with subclinical hypothyroidism during pregnancy. CONCLUSION: Fluctuations in TSH and free T4 during pregnancy parallel reported obstetric values. African Americans demonstrated consistently lower TSH levels than whites. These differences were unexplained by racial differences in either TPO antibody seropositivity, iodine status, or chorionic gonadotropin levels.

Original languageEnglish (US)
Pages (from-to)1365-1371
Number of pages7
JournalObstetrics and Gynecology
Volume106
Issue number6
StatePublished - Dec 2005
Externally publishedYes

Fingerprint

Autoimmunity
Postpartum Period
Iodide Peroxidase
Thyroid Gland
African Americans
Thyrotropin
Pregnancy
Third Pregnancy Trimester
Iodine
Antibodies
Chorionic Gonadotropin
First Pregnancy Trimester
Hypothyroidism
Thyroxine
Obstetrics
Urine
Serum

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Walker, J. A., Illions, E. H., Huddleston, J. F., & Smallridge, R. C. (2005). Racial comparisons of thyroid function and autoimmunity during pregnancy and the postpartum period. Obstetrics and Gynecology, 106(6), 1365-1371.

Racial comparisons of thyroid function and autoimmunity during pregnancy and the postpartum period. / Walker, Jason A.; Illions, Edward H.; Huddleston, John F.; Smallridge, Robert C.

In: Obstetrics and Gynecology, Vol. 106, No. 6, 12.2005, p. 1365-1371.

Research output: Contribution to journalArticle

Walker, JA, Illions, EH, Huddleston, JF & Smallridge, RC 2005, 'Racial comparisons of thyroid function and autoimmunity during pregnancy and the postpartum period', Obstetrics and Gynecology, vol. 106, no. 6, pp. 1365-1371.
Walker JA, Illions EH, Huddleston JF, Smallridge RC. Racial comparisons of thyroid function and autoimmunity during pregnancy and the postpartum period. Obstetrics and Gynecology. 2005 Dec;106(6):1365-1371.
Walker, Jason A. ; Illions, Edward H. ; Huddleston, John F. ; Smallridge, Robert C. / Racial comparisons of thyroid function and autoimmunity during pregnancy and the postpartum period. In: Obstetrics and Gynecology. 2005 ; Vol. 106, No. 6. pp. 1365-1371.
@article{bd4401832b62474eadf3b6dc71e32d2a,
title = "Racial comparisons of thyroid function and autoimmunity during pregnancy and the postpartum period",
abstract = "OBJECTIVE: To evaluate thyroid function and the prevalence of thyroid peroxidase (TPO) antibody and autoimmunity in African-American and white women during pregnancy and the postpartum period. METHODS: Five hundred eighty-nine women were evaluated prospectively. Serum thyroid-stimulating hormone (TSH), free thyroxine (T4), and TPO, Ro, and La antibodies were obtained during pregnancy, at delivery, and postpartum. Levels of hCG were determined during pregnancy. Urinary iodine levels were evaluated in the third trimester in another group of women. All TPO antibody-positive patients were to be followed up at 3 and 6 months postpartum. RESULTS: African-American women had lower TSH values than white women at all times. Thyroid-stimulating hormone increased, and free T4 decreased from the first to third trimester of pregnancy for both groups. African Americans had higher hCG levels than whites in the first trimester but not in the third trimester. There was no difference in urine iodine excretion between African-American and white women. Finally, there was no difference in TPO antibody seropositivity between African-American and white women. Overall, 5 patients (0.8{\%}) were diagnosed with subclinical hypothyroidism during pregnancy. CONCLUSION: Fluctuations in TSH and free T4 during pregnancy parallel reported obstetric values. African Americans demonstrated consistently lower TSH levels than whites. These differences were unexplained by racial differences in either TPO antibody seropositivity, iodine status, or chorionic gonadotropin levels.",
author = "Walker, {Jason A.} and Illions, {Edward H.} and Huddleston, {John F.} and Smallridge, {Robert C.}",
year = "2005",
month = "12",
language = "English (US)",
volume = "106",
pages = "1365--1371",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Racial comparisons of thyroid function and autoimmunity during pregnancy and the postpartum period

AU - Walker, Jason A.

AU - Illions, Edward H.

AU - Huddleston, John F.

AU - Smallridge, Robert C.

PY - 2005/12

Y1 - 2005/12

N2 - OBJECTIVE: To evaluate thyroid function and the prevalence of thyroid peroxidase (TPO) antibody and autoimmunity in African-American and white women during pregnancy and the postpartum period. METHODS: Five hundred eighty-nine women were evaluated prospectively. Serum thyroid-stimulating hormone (TSH), free thyroxine (T4), and TPO, Ro, and La antibodies were obtained during pregnancy, at delivery, and postpartum. Levels of hCG were determined during pregnancy. Urinary iodine levels were evaluated in the third trimester in another group of women. All TPO antibody-positive patients were to be followed up at 3 and 6 months postpartum. RESULTS: African-American women had lower TSH values than white women at all times. Thyroid-stimulating hormone increased, and free T4 decreased from the first to third trimester of pregnancy for both groups. African Americans had higher hCG levels than whites in the first trimester but not in the third trimester. There was no difference in urine iodine excretion between African-American and white women. Finally, there was no difference in TPO antibody seropositivity between African-American and white women. Overall, 5 patients (0.8%) were diagnosed with subclinical hypothyroidism during pregnancy. CONCLUSION: Fluctuations in TSH and free T4 during pregnancy parallel reported obstetric values. African Americans demonstrated consistently lower TSH levels than whites. These differences were unexplained by racial differences in either TPO antibody seropositivity, iodine status, or chorionic gonadotropin levels.

AB - OBJECTIVE: To evaluate thyroid function and the prevalence of thyroid peroxidase (TPO) antibody and autoimmunity in African-American and white women during pregnancy and the postpartum period. METHODS: Five hundred eighty-nine women were evaluated prospectively. Serum thyroid-stimulating hormone (TSH), free thyroxine (T4), and TPO, Ro, and La antibodies were obtained during pregnancy, at delivery, and postpartum. Levels of hCG were determined during pregnancy. Urinary iodine levels were evaluated in the third trimester in another group of women. All TPO antibody-positive patients were to be followed up at 3 and 6 months postpartum. RESULTS: African-American women had lower TSH values than white women at all times. Thyroid-stimulating hormone increased, and free T4 decreased from the first to third trimester of pregnancy for both groups. African Americans had higher hCG levels than whites in the first trimester but not in the third trimester. There was no difference in urine iodine excretion between African-American and white women. Finally, there was no difference in TPO antibody seropositivity between African-American and white women. Overall, 5 patients (0.8%) were diagnosed with subclinical hypothyroidism during pregnancy. CONCLUSION: Fluctuations in TSH and free T4 during pregnancy parallel reported obstetric values. African Americans demonstrated consistently lower TSH levels than whites. These differences were unexplained by racial differences in either TPO antibody seropositivity, iodine status, or chorionic gonadotropin levels.

UR - http://www.scopus.com/inward/record.url?scp=27944433029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27944433029&partnerID=8YFLogxK

M3 - Article

C2 - 16319264

AN - SCOPUS:27944433029

VL - 106

SP - 1365

EP - 1371

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 6

ER -