Racial and ethnic disparities in survival in lung transplant candidates with idiopathic pulmonary fibrosis

D. J. Lederer, C. E. Caplan-Shaw, M. K. O'Shea, J. S. Wilt, R. C. Basner, Matthew N. Bartels, J. R. Sonett, S. M. Arcasoy, S. M. Kawut

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Minority patients have worse outcomes than nonminority patients in a variety of pulmonary diseases. We aimed to compare the survival of Black and Hispanic patients to that of others with idiopathic pulmonary fibrosis (IPF). We performed a retrospective cohort study of patients with IPF who were evaluated for lung transplantation at our center. Kaplan-Meier survival curves and Cox proportional hazards models were used to compare survival between groups. Black and Hispanic patients had spirometry, lung volumes and diffusion capacity that were similar to others, but had worse exercise capacity. Minority patients had a significantly increased risk of death compared to others independent of transplantation status (hazard ratio = 3.3, 95% CI 1.2-8.9, p = 0.02). Differences in exercise capacity, pulmonary hemodynamics and socioeconomic factors appeared to account for some of the differences in survival. Black and Hispanic patients with IPF had an increased risk of death following referral for lung transplantation. This finding may be due to differences in disease progression and/or differences in access to medical care among minority patients. Future studies should confirm our findings in a larger cohort. The elimination of racial and ethnic disparities in outcome should be a priority for clinicians and researchers in this field.

Original languageEnglish (US)
Pages (from-to)398-403
Number of pages6
JournalAmerican Journal of Transplantation
Volume6
Issue number2
DOIs
StatePublished - Feb 2006
Externally publishedYes

Fingerprint

Idiopathic Pulmonary Fibrosis
Transplants
Lung
Survival
Hispanic Americans
Lung Transplantation
Exercise
Spirometry
Kaplan-Meier Estimate
Proportional Hazards Models
Lung Diseases
Disease Progression
Cohort Studies
Referral and Consultation
Retrospective Studies
Transplantation
Hemodynamics
Research Personnel

Keywords

  • Idiopathic pulmonary fibrosis
  • Lung transplantation
  • Survival

ASJC Scopus subject areas

  • Immunology

Cite this

Racial and ethnic disparities in survival in lung transplant candidates with idiopathic pulmonary fibrosis. / Lederer, D. J.; Caplan-Shaw, C. E.; O'Shea, M. K.; Wilt, J. S.; Basner, R. C.; Bartels, Matthew N.; Sonett, J. R.; Arcasoy, S. M.; Kawut, S. M.

In: American Journal of Transplantation, Vol. 6, No. 2, 02.2006, p. 398-403.

Research output: Contribution to journalArticle

Lederer, DJ, Caplan-Shaw, CE, O'Shea, MK, Wilt, JS, Basner, RC, Bartels, MN, Sonett, JR, Arcasoy, SM & Kawut, SM 2006, 'Racial and ethnic disparities in survival in lung transplant candidates with idiopathic pulmonary fibrosis', American Journal of Transplantation, vol. 6, no. 2, pp. 398-403. https://doi.org/10.1111/j.1600-6143.2005.01205.x
Lederer, D. J. ; Caplan-Shaw, C. E. ; O'Shea, M. K. ; Wilt, J. S. ; Basner, R. C. ; Bartels, Matthew N. ; Sonett, J. R. ; Arcasoy, S. M. ; Kawut, S. M. / Racial and ethnic disparities in survival in lung transplant candidates with idiopathic pulmonary fibrosis. In: American Journal of Transplantation. 2006 ; Vol. 6, No. 2. pp. 398-403.
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