Race, ABO blood group, and venous thromboembolism risk: Not black and white

Chunhui Fang, Hillel W. Cohen, Henny H. Billett

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

BACKGROUND: The rate of venous thromboembolism (VTE) has been reported to be higher in blacks compared to whites. Non-O blood groups have also been associated with a significantly higher VTE risk. Given that a higher proportion of blacks have O blood group, one might have expected that black individuals would have fewer VTEs. STUDY DESIGN AND METHODS: In this study, we analyzed race, sex, age, ABO or Rh blood group, and VTE risk in 60,982 black and white patients admitted over a span of 10 years. RESULTS: The overall occurrence of VTEs was 7.6%, higher in males (8.7% males vs. 7.2% females), higher in non-O blood groups (8.5% non-O vs. 6.9% O blood group), and increased with age (5.8% <65 years, 11.3% ≥65 years). No difference in VTE rate was noted with Rh antigen positivity. When stratified by age, VTE rate was consistently higher in blacks and non-O blood groups. No difference was detected among the various non-O blood groups. To assess the potential confounder of comorbidities, we stratified patients according to Charlson comorbidity score. In a subgroup of healthy patients with age-independent Charlson comorbidity scores of 0 (n = 28,387), blacks still had an increased VTE risk and this risk was still higher with increasing age and in those with non-O blood groups. CONCLUSION: We conclude that black race and non-O blood groups have increased VTE risk when stratified for age and that associated comorbidities do not explain these differences.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalTransfusion
Volume53
Issue number1
DOIs
StatePublished - Jan 2013

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Venous Thromboembolism
Blood Group Antigens
Comorbidity
hydroquinone
Antigens

ASJC Scopus subject areas

  • Hematology
  • Immunology
  • Immunology and Allergy

Cite this

Race, ABO blood group, and venous thromboembolism risk : Not black and white. / Fang, Chunhui; Cohen, Hillel W.; Billett, Henny H.

In: Transfusion, Vol. 53, No. 1, 01.2013, p. 187-192.

Research output: Contribution to journalArticle

Fang, Chunhui ; Cohen, Hillel W. ; Billett, Henny H. / Race, ABO blood group, and venous thromboembolism risk : Not black and white. In: Transfusion. 2013 ; Vol. 53, No. 1. pp. 187-192.
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abstract = "BACKGROUND: The rate of venous thromboembolism (VTE) has been reported to be higher in blacks compared to whites. Non-O blood groups have also been associated with a significantly higher VTE risk. Given that a higher proportion of blacks have O blood group, one might have expected that black individuals would have fewer VTEs. STUDY DESIGN AND METHODS: In this study, we analyzed race, sex, age, ABO or Rh blood group, and VTE risk in 60,982 black and white patients admitted over a span of 10 years. RESULTS: The overall occurrence of VTEs was 7.6{\%}, higher in males (8.7{\%} males vs. 7.2{\%} females), higher in non-O blood groups (8.5{\%} non-O vs. 6.9{\%} O blood group), and increased with age (5.8{\%} <65 years, 11.3{\%} ≥65 years). No difference in VTE rate was noted with Rh antigen positivity. When stratified by age, VTE rate was consistently higher in blacks and non-O blood groups. No difference was detected among the various non-O blood groups. To assess the potential confounder of comorbidities, we stratified patients according to Charlson comorbidity score. In a subgroup of healthy patients with age-independent Charlson comorbidity scores of 0 (n = 28,387), blacks still had an increased VTE risk and this risk was still higher with increasing age and in those with non-O blood groups. CONCLUSION: We conclude that black race and non-O blood groups have increased VTE risk when stratified for age and that associated comorbidities do not explain these differences.",
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