Quinolizinium as a new fluorescent lysosomotropic probe

Emmanouil Zacharioudakis, Tatiana Cañeque, Raúl Custodio, Sebastian Müller, Ana M. Cuadro, Juan J. Vaquero, Raphaël Rodriguez

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

We have synthesized a collection of quinolizinium fluorescent dyes for the purpose of cell imaging. Preliminary biological studies in human U2OS osteosarcoma cancer cells have shown that different functional groups appended to the cationic quinolizinium scaffold efficiently modulate photophysical properties but also cellular distribution. While quinolizinium probes are known nuclear staining reagents, we have identified a particular quinolizinium derivative salt that targets the lysosomal compartment. This finding raises the question of predictability of specific organelle targeting from structural features of small molecules.

Original languageEnglish (US)
Pages (from-to)203-207
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume27
Issue number2
DOIs
StatePublished - 2017
Externally publishedYes

Keywords

  • Fluorescent dyes
  • Heteroaromatic cations
  • Lysosomal probes
  • Quinolizinium
  • Small molecules

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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