Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes

Thomas S. Hermann, Weijie Li, Helena Dominguez, Nikolaj Ihlemann, Christian Rask-Madsen, Atheline Major-Pedersen, Dorthe Baunbjerg Nielsen, Kaj Winther Hansen, Meredith A. Hawkins, Lars Kober, Christian Torp-Pedersen

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Objective: Angiotensin-converting enzyme inhibitors reduce cardiovascular mortality and improve endothelial function in type 2 diabetic patients. We hypothesized that 2 months of quinapril treatment would improve insulin-stimulated endothelial function and glucose uptake in type 2 diabetic subjects and simultaneously increase the expression of genes that are pertinent for endothelial function and metabolism. Methods: Twenty-four type 2 diabetic subjects were randomized to receive 2 months of quinapril 20 mg daily or no treatment in an open parallel study. Endothelium-dependent and -independent vasodilation was studied during serotonin or sodium nitroprusside infusion in the diabetic patients and in 15 healthy subjects. Endothelial function, insulin-stimulated endothelial function, and insulin-stimulated glucose uptake were measured before and after quinapril treatment. Blood flow was measured by venous occlusion plethysmography. Gene expression was measured by real-time PCR. Results: Quinapril treatment increased insulin-stimulated endothelial function in the type 2 diabetic subjects (P = 0.005), whereas forearm glucose uptake was unchanged. Endothelial function was also increased by quinapril (P = 0.001). Systolic and diastolic blood pressures were reduced by quinapril (P < 0.001). Quinapril increased adiponectin gene expression in vascular tissue obtained from sc adipose biopsies. Conclusions: Quinapril treatment increases insulin-stimulated endothelial function in patients with type 2 diabetes. Increased vascular adiponectin gene expression may contribute to this beneficial effect.

Original languageEnglish (US)
Pages (from-to)1001-1008
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume91
Issue number3
DOIs
StatePublished - Mar 2006

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Adiponectin
Medical problems
Gene expression
Type 2 Diabetes Mellitus
Insulin
Gene Expression
Therapeutics
Glucose
Blood Vessels
Plethysmography
Blood Pressure
quinapril
Biopsy
Blood pressure
Nitroprusside
Angiotensin-Converting Enzyme Inhibitors
Forearm
Metabolism
Vasodilation
Endothelium

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes. / Hermann, Thomas S.; Li, Weijie; Dominguez, Helena; Ihlemann, Nikolaj; Rask-Madsen, Christian; Major-Pedersen, Atheline; Nielsen, Dorthe Baunbjerg; Hansen, Kaj Winther; Hawkins, Meredith A.; Kober, Lars; Torp-Pedersen, Christian.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 91, No. 3, 03.2006, p. 1001-1008.

Research output: Contribution to journalArticle

Hermann, TS, Li, W, Dominguez, H, Ihlemann, N, Rask-Madsen, C, Major-Pedersen, A, Nielsen, DB, Hansen, KW, Hawkins, MA, Kober, L & Torp-Pedersen, C 2006, 'Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes', Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 3, pp. 1001-1008. https://doi.org/10.1210/jc.2005-1231
Hermann, Thomas S. ; Li, Weijie ; Dominguez, Helena ; Ihlemann, Nikolaj ; Rask-Madsen, Christian ; Major-Pedersen, Atheline ; Nielsen, Dorthe Baunbjerg ; Hansen, Kaj Winther ; Hawkins, Meredith A. ; Kober, Lars ; Torp-Pedersen, Christian. / Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes. In: Journal of Clinical Endocrinology and Metabolism. 2006 ; Vol. 91, No. 3. pp. 1001-1008.
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AU - Nielsen, Dorthe Baunbjerg

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