Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells

J. H. Kim, S. H. Kim, A. A. Alfieri, C. W. Young

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Since cancer cells produce large amounts of lactate via aerobic glycolysis and since an acidic pH has been shown to selectively enhance the cytotoxic effects of hyperthermia, we are examining the influence of cell exposure to drugs which inhibit lactate transport and lower intracellular pH upon cytotoxic effects of hyperthermia. Quercetin, a bioflavonoid that produces lactate transport inhibition, was not cytotoxic up to 4 hr at 37° (0.1 mM). When HeLa cells were exposed to quercetin at 41 and 42° , significant potentiation of hyperthermia-induced cytotoxicity was observed. The magnitude of the potentiation was dependent on the drug concentration, pH of the culture medium, temperature, and duration of treatment. In contrast, treatment of cells with rutin, a structurally related bioflavonoid that lacks the property of lactate transport inhibition, showed no hyperthermic potentiation.

Original languageEnglish (US)
Pages (from-to)102-106
Number of pages5
JournalCancer Research
Volume44
Issue number1
StatePublished - 1984
Externally publishedYes

Fingerprint

Quercetin
HeLa Cells
Lactic Acid
Flavonoids
Fever
Rutin
Induced Hyperthermia
Glycolysis
Pharmaceutical Preparations
Culture Media
Temperature
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kim, J. H., Kim, S. H., Alfieri, A. A., & Young, C. W. (1984). Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells. Cancer Research, 44(1), 102-106.

Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells. / Kim, J. H.; Kim, S. H.; Alfieri, A. A.; Young, C. W.

In: Cancer Research, Vol. 44, No. 1, 1984, p. 102-106.

Research output: Contribution to journalArticle

Kim, JH, Kim, SH, Alfieri, AA & Young, CW 1984, 'Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells', Cancer Research, vol. 44, no. 1, pp. 102-106.
Kim, J. H. ; Kim, S. H. ; Alfieri, A. A. ; Young, C. W. / Quercetin, an inhibitor of lactate transport and a hyperthermic sensitizer of HeLa cells. In: Cancer Research. 1984 ; Vol. 44, No. 1. pp. 102-106.
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