Quantitative Ultrasound for Monitoring High-Intensity Focused Ultrasound TreatmentIn Vivo

Goutam Ghoshal, Jeremy P. Kemmerer, Chandra Karunakaran, Rita J. Miller, Michael L. Oelze

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The success of any minimally invasive treatment procedure can be enhanced significantly if combined with a robust noninvasive imaging modality that can monitor therapy in real time. Quantitative ultrasound (QUS) imaging has been widely investigated for monitoring various treatment responses such as chemotherapy, radiation, and thermal therapy. Previously, we demonstrated the feasibility of using spectral-based QUS parameters to monitor high-intensity focused ultrasound (HIFU) treatment of in situ tumors in euthanized rats [Ultrasonic Imaging 36(4), 239.255, 2014]. In the present study, we examined the use of spectral-based QUS parameters to monitor HIFU treatment of in vivo rat mammary adenocarcinoma tumors (MAT) where significant tissue motion was present. HIFU was applied to tumors in rats using a single-element transducer. During the off part of the HIFU duty cycle, ultrasound backscatter was recorded from the tumors using a linear array co-aligned with the HIFU focus. A total of 10 rats were treated with HIFU in this study with an additional sham-treated rat. Spectral parameters from the backscatter coefficient, i.e., effective scatterer diameter (ESD) and effective acoustic concentration (EAC), were estimated. The changes of each parameter during treatment were compared with a temperature profile recorded by a fine-needle thermocouple inserted into the tumor a few millimeters behind the focus of the HIFU transducer. The mean ESD changed from 121 ± 6 to 81 ± 8 μm(p-value = 0.0002), and the EAC changed from 33 ± 2 to 46 ± 3 dB/cm3 (p-value = 0.0002) during HIFU exposure as the temperature increased on average from 38.7 ± 1.0 °C to 64.2 ± 2.7 °C. The changes in ESD and EAC were linearly correlated with the changes in tissue temperature during the treatment. When HIFU was turned off, the ESD increased from 81 ± 8 to 121 ± 7 μm and the EAC dropped from 46 ± 3to 36 ± 2 dB/cm3 as the temperature decreased from 64.2 ± 2.7 °C to 45 ± 2.7 °C. QUS was demonstrated in vivo to track temperature elevations caused by HIFU exposure.

Original languageEnglish (US)
Article number7383302
Pages (from-to)1234-1242
Number of pages9
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume63
Issue number9
DOIs
StatePublished - Sep 2016
Externally publishedYes

Fingerprint

Ultrasonics
Monitoring
rats
tumors
Rats
Tumors
therapy
acoustics
Acoustics
scattering
transducers
temperature
Transducers
linear arrays
chemotherapy
thermocouples
Temperature
needles
temperature profiles
Tissue

Keywords

  • Backscatter coefficient (BSC)
  • focused ultrasound
  • quantitative ultrasound (QUS) imaging
  • ultrasound-based therapy

ASJC Scopus subject areas

  • Instrumentation
  • Acoustics and Ultrasonics
  • Electrical and Electronic Engineering

Cite this

Quantitative Ultrasound for Monitoring High-Intensity Focused Ultrasound TreatmentIn Vivo. / Ghoshal, Goutam; Kemmerer, Jeremy P.; Karunakaran, Chandra; Miller, Rita J.; Oelze, Michael L.

In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 63, No. 9, 7383302, 09.2016, p. 1234-1242.

Research output: Contribution to journalArticle

Ghoshal, Goutam ; Kemmerer, Jeremy P. ; Karunakaran, Chandra ; Miller, Rita J. ; Oelze, Michael L. / Quantitative Ultrasound for Monitoring High-Intensity Focused Ultrasound TreatmentIn Vivo. In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 2016 ; Vol. 63, No. 9. pp. 1234-1242.
@article{d051ca89fe724669ae94a18a416c378c,
title = "Quantitative Ultrasound for Monitoring High-Intensity Focused Ultrasound TreatmentIn Vivo",
abstract = "The success of any minimally invasive treatment procedure can be enhanced significantly if combined with a robust noninvasive imaging modality that can monitor therapy in real time. Quantitative ultrasound (QUS) imaging has been widely investigated for monitoring various treatment responses such as chemotherapy, radiation, and thermal therapy. Previously, we demonstrated the feasibility of using spectral-based QUS parameters to monitor high-intensity focused ultrasound (HIFU) treatment of in situ tumors in euthanized rats [Ultrasonic Imaging 36(4), 239.255, 2014]. In the present study, we examined the use of spectral-based QUS parameters to monitor HIFU treatment of in vivo rat mammary adenocarcinoma tumors (MAT) where significant tissue motion was present. HIFU was applied to tumors in rats using a single-element transducer. During the off part of the HIFU duty cycle, ultrasound backscatter was recorded from the tumors using a linear array co-aligned with the HIFU focus. A total of 10 rats were treated with HIFU in this study with an additional sham-treated rat. Spectral parameters from the backscatter coefficient, i.e., effective scatterer diameter (ESD) and effective acoustic concentration (EAC), were estimated. The changes of each parameter during treatment were compared with a temperature profile recorded by a fine-needle thermocouple inserted into the tumor a few millimeters behind the focus of the HIFU transducer. The mean ESD changed from 121 ± 6 to 81 ± 8 μm(p-value = 0.0002), and the EAC changed from 33 ± 2 to 46 ± 3 dB/cm3 (p-value = 0.0002) during HIFU exposure as the temperature increased on average from 38.7 ± 1.0 °C to 64.2 ± 2.7 °C. The changes in ESD and EAC were linearly correlated with the changes in tissue temperature during the treatment. When HIFU was turned off, the ESD increased from 81 ± 8 to 121 ± 7 μm and the EAC dropped from 46 ± 3to 36 ± 2 dB/cm3 as the temperature decreased from 64.2 ± 2.7 °C to 45 ± 2.7 °C. QUS was demonstrated in vivo to track temperature elevations caused by HIFU exposure.",
keywords = "Backscatter coefficient (BSC), focused ultrasound, quantitative ultrasound (QUS) imaging, ultrasound-based therapy",
author = "Goutam Ghoshal and Kemmerer, {Jeremy P.} and Chandra Karunakaran and Miller, {Rita J.} and Oelze, {Michael L.}",
year = "2016",
month = "9",
doi = "10.1109/TUFFC.2016.2517644",
language = "English (US)",
volume = "63",
pages = "1234--1242",
journal = "IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control",
issn = "0885-3010",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "9",

}

TY - JOUR

T1 - Quantitative Ultrasound for Monitoring High-Intensity Focused Ultrasound TreatmentIn Vivo

AU - Ghoshal, Goutam

AU - Kemmerer, Jeremy P.

AU - Karunakaran, Chandra

AU - Miller, Rita J.

AU - Oelze, Michael L.

PY - 2016/9

Y1 - 2016/9

N2 - The success of any minimally invasive treatment procedure can be enhanced significantly if combined with a robust noninvasive imaging modality that can monitor therapy in real time. Quantitative ultrasound (QUS) imaging has been widely investigated for monitoring various treatment responses such as chemotherapy, radiation, and thermal therapy. Previously, we demonstrated the feasibility of using spectral-based QUS parameters to monitor high-intensity focused ultrasound (HIFU) treatment of in situ tumors in euthanized rats [Ultrasonic Imaging 36(4), 239.255, 2014]. In the present study, we examined the use of spectral-based QUS parameters to monitor HIFU treatment of in vivo rat mammary adenocarcinoma tumors (MAT) where significant tissue motion was present. HIFU was applied to tumors in rats using a single-element transducer. During the off part of the HIFU duty cycle, ultrasound backscatter was recorded from the tumors using a linear array co-aligned with the HIFU focus. A total of 10 rats were treated with HIFU in this study with an additional sham-treated rat. Spectral parameters from the backscatter coefficient, i.e., effective scatterer diameter (ESD) and effective acoustic concentration (EAC), were estimated. The changes of each parameter during treatment were compared with a temperature profile recorded by a fine-needle thermocouple inserted into the tumor a few millimeters behind the focus of the HIFU transducer. The mean ESD changed from 121 ± 6 to 81 ± 8 μm(p-value = 0.0002), and the EAC changed from 33 ± 2 to 46 ± 3 dB/cm3 (p-value = 0.0002) during HIFU exposure as the temperature increased on average from 38.7 ± 1.0 °C to 64.2 ± 2.7 °C. The changes in ESD and EAC were linearly correlated with the changes in tissue temperature during the treatment. When HIFU was turned off, the ESD increased from 81 ± 8 to 121 ± 7 μm and the EAC dropped from 46 ± 3to 36 ± 2 dB/cm3 as the temperature decreased from 64.2 ± 2.7 °C to 45 ± 2.7 °C. QUS was demonstrated in vivo to track temperature elevations caused by HIFU exposure.

AB - The success of any minimally invasive treatment procedure can be enhanced significantly if combined with a robust noninvasive imaging modality that can monitor therapy in real time. Quantitative ultrasound (QUS) imaging has been widely investigated for monitoring various treatment responses such as chemotherapy, radiation, and thermal therapy. Previously, we demonstrated the feasibility of using spectral-based QUS parameters to monitor high-intensity focused ultrasound (HIFU) treatment of in situ tumors in euthanized rats [Ultrasonic Imaging 36(4), 239.255, 2014]. In the present study, we examined the use of spectral-based QUS parameters to monitor HIFU treatment of in vivo rat mammary adenocarcinoma tumors (MAT) where significant tissue motion was present. HIFU was applied to tumors in rats using a single-element transducer. During the off part of the HIFU duty cycle, ultrasound backscatter was recorded from the tumors using a linear array co-aligned with the HIFU focus. A total of 10 rats were treated with HIFU in this study with an additional sham-treated rat. Spectral parameters from the backscatter coefficient, i.e., effective scatterer diameter (ESD) and effective acoustic concentration (EAC), were estimated. The changes of each parameter during treatment were compared with a temperature profile recorded by a fine-needle thermocouple inserted into the tumor a few millimeters behind the focus of the HIFU transducer. The mean ESD changed from 121 ± 6 to 81 ± 8 μm(p-value = 0.0002), and the EAC changed from 33 ± 2 to 46 ± 3 dB/cm3 (p-value = 0.0002) during HIFU exposure as the temperature increased on average from 38.7 ± 1.0 °C to 64.2 ± 2.7 °C. The changes in ESD and EAC were linearly correlated with the changes in tissue temperature during the treatment. When HIFU was turned off, the ESD increased from 81 ± 8 to 121 ± 7 μm and the EAC dropped from 46 ± 3to 36 ± 2 dB/cm3 as the temperature decreased from 64.2 ± 2.7 °C to 45 ± 2.7 °C. QUS was demonstrated in vivo to track temperature elevations caused by HIFU exposure.

KW - Backscatter coefficient (BSC)

KW - focused ultrasound

KW - quantitative ultrasound (QUS) imaging

KW - ultrasound-based therapy

UR - http://www.scopus.com/inward/record.url?scp=84988799935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988799935&partnerID=8YFLogxK

U2 - 10.1109/TUFFC.2016.2517644

DO - 10.1109/TUFFC.2016.2517644

M3 - Article

AN - SCOPUS:84988799935

VL - 63

SP - 1234

EP - 1242

JO - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

JF - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

SN - 0885-3010

IS - 9

M1 - 7383302

ER -