TY - JOUR
T1 - Quantitative Real-time 3-Dimensional Stress Echocardiography
T2 - A Preliminary Investigation of Feasibility and Effectiveness
AU - Walimbe, Vivek
AU - Garcia, Mario
AU - Lalude, Omosalewa
AU - Thomas, James
AU - Shekhar, Raj
N1 - Funding Information:
Supported by the Whitaker Foundation research grant RG-01-0071 and in part by the American Heart Association predoctoral fellowship grant 0415141B.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2007/1
Y1 - 2007/1
N2 - Background: Use of rapidly emerging real-time 3-dimensional (3D) echocardiography promises to improve the diagnostic accuracy of stress echocardiography (SE). However, widespread acceptance of 3D-SE, based on real-time 3D echocardiography, is hampered in part by lack of efficient, accurate, and objective analysis tools. Methods: We propose novel algorithms for interactive visualization, registration (alignment), and quantitative analysis of prestress and poststress real-time 3D echocardiography to facilitate an objective diagnosis. In a preliminary evaluation, two experts independently performed wall-motion analysis in 15 patients with known/suspected coronary artery disease, using the novel quantitative 3D-SE methods. Results: Compared with previously reported values for conventional 2-dimensional SE, improved interexpert agreement (κ = 0.85) was observed for segment-wise classification of normal/abnormal wall motion using the novel 3D-SE methods. Overall, 6 of 6 patients with abnormal myocardial segments were correctly identified by both experts with 3D-SE, compared with 4 of 6 with conventional 2-dimensional SE. Conclusion: Initial results are promising and indicate the feasibility and potential of our proposed quantitative 3D-SE methodologies for improving diagnosis of wall-motion abnormalities.
AB - Background: Use of rapidly emerging real-time 3-dimensional (3D) echocardiography promises to improve the diagnostic accuracy of stress echocardiography (SE). However, widespread acceptance of 3D-SE, based on real-time 3D echocardiography, is hampered in part by lack of efficient, accurate, and objective analysis tools. Methods: We propose novel algorithms for interactive visualization, registration (alignment), and quantitative analysis of prestress and poststress real-time 3D echocardiography to facilitate an objective diagnosis. In a preliminary evaluation, two experts independently performed wall-motion analysis in 15 patients with known/suspected coronary artery disease, using the novel quantitative 3D-SE methods. Results: Compared with previously reported values for conventional 2-dimensional SE, improved interexpert agreement (κ = 0.85) was observed for segment-wise classification of normal/abnormal wall motion using the novel 3D-SE methods. Overall, 6 of 6 patients with abnormal myocardial segments were correctly identified by both experts with 3D-SE, compared with 4 of 6 with conventional 2-dimensional SE. Conclusion: Initial results are promising and indicate the feasibility and potential of our proposed quantitative 3D-SE methodologies for improving diagnosis of wall-motion abnormalities.
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U2 - 10.1016/j.echo.2006.07.012
DO - 10.1016/j.echo.2006.07.012
M3 - Article
C2 - 17218197
AN - SCOPUS:33846018962
SN - 0894-7317
VL - 20
SP - 13
EP - 22
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 1
ER -