Abstract
Quantitative footprinting techniques allow a detailed analysis of the thermodynamic forces that characterize nucleic acid-ligand interactions and ligand-induced changes in nucleic acid structure by separately resolving the intrinsic and cooperative Gibbs free energy changes describing the reactions being investigated. A new implementation of the quantitative footprinting technique is the application of stopped-flow techniques to the study of kinetic reactions.
Original language | English (US) |
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Pages (from-to) | 36-44 |
Number of pages | 9 |
Journal | Current Opinion in Biotechnology |
Volume | 8 |
Issue number | 1 |
DOIs | |
State | Published - 1997 |
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering