Quantitative nucleic acids footprinting: Thermodynamic and kinetic approaches

Victoria Petri, Michael Brenowitz

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Quantitative footprinting techniques allow a detailed analysis of the thermodynamic forces that characterize nucleic acid-ligand interactions and ligand-induced changes in nucleic acid structure by separately resolving the intrinsic and cooperative Gibbs free energy changes describing the reactions being investigated. A new implementation of the quantitative footprinting technique is the application of stopped-flow techniques to the study of kinetic reactions.

Original languageEnglish (US)
Pages (from-to)36-44
Number of pages9
JournalCurrent Opinion in Biotechnology
Volume8
Issue number1
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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