Quantitative electroencephalographic subtyping of obsessive-compulsive disorder

Leslie S. Prichep, Francis Mas, Eric Hollander, Michael Liebowitz, E. Roy John, Mary Almas, Concetta M. Decaria, Robert H. Levine

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Current neuropsychological, electrophysiological, and other imaging data strongly suggest the existence of a neurobiological basis for obsessive-compulsive disorder (OCD), which was long considered to be exclusively of psychogenic origin. The positive response of some OCD patients to neurosurgery, as well as the efficacy of agents that selectively block serotonin reuptake, lends further support to a biological involvement. However, a survey of the treatment literature reveals that only 45-62% of OCD patients improve with these specific medications. In a pilot study using a quantitative electroencephalographic (QEEG) method known as neurometrics, in which QEEG data from OCD patients were compared statistically with those from an age-appropriate normative population, we previously reported the existence of two subtypes of OCD patients within a clinically homogeneous group of patients who met DSM III-R criteria for OCD. Following pharmacological treatment, a clear relationship was found between treatment response and neurometric cluster membership. In this study, we have expanded the OCD population, adding patients from a second site, and have replicated the existence of two clusters of patients in an enlarged, statistically more robust population. Cluster I was characterized by excess relative power in theta, especially in the frontal and frontotemporal regions; cluster 2 was characterized by increased relative power in alpha. Further, 80.0% of the members of cluster 1 were found to be nonresponders to drug treatment, while 82.4% of the members of cluster 2 were found to be treatment responders. These findings suggest the existence of at least two pathophysiological subgroups within the OCD population that share a common clinical expression, but show a differential response to treatment with serotonin reuptake inhibitors.

Original languageEnglish (US)
Pages (from-to)25-32
Number of pages8
JournalPsychiatry Research
Volume50
Issue number1
StatePublished - Apr 1993
Externally publishedYes

Fingerprint

Obsessive-Compulsive Disorder
Population
Therapeutics
Serotonin Uptake Inhibitors
Neurosurgery
Diagnostic and Statistical Manual of Mental Disorders
Serotonin
Pharmacology
Pharmaceutical Preparations

Keywords

  • brain mapping
  • Neurometrics
  • serotonin reuptake inhibitors

ASJC Scopus subject areas

  • Psychology(all)
  • Biological Psychiatry
  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging

Cite this

Prichep, L. S., Mas, F., Hollander, E., Liebowitz, M., John, E. R., Almas, M., ... Levine, R. H. (1993). Quantitative electroencephalographic subtyping of obsessive-compulsive disorder. Psychiatry Research, 50(1), 25-32.

Quantitative electroencephalographic subtyping of obsessive-compulsive disorder. / Prichep, Leslie S.; Mas, Francis; Hollander, Eric; Liebowitz, Michael; John, E. Roy; Almas, Mary; Decaria, Concetta M.; Levine, Robert H.

In: Psychiatry Research, Vol. 50, No. 1, 04.1993, p. 25-32.

Research output: Contribution to journalArticle

Prichep, LS, Mas, F, Hollander, E, Liebowitz, M, John, ER, Almas, M, Decaria, CM & Levine, RH 1993, 'Quantitative electroencephalographic subtyping of obsessive-compulsive disorder', Psychiatry Research, vol. 50, no. 1, pp. 25-32.
Prichep LS, Mas F, Hollander E, Liebowitz M, John ER, Almas M et al. Quantitative electroencephalographic subtyping of obsessive-compulsive disorder. Psychiatry Research. 1993 Apr;50(1):25-32.
Prichep, Leslie S. ; Mas, Francis ; Hollander, Eric ; Liebowitz, Michael ; John, E. Roy ; Almas, Mary ; Decaria, Concetta M. ; Levine, Robert H. / Quantitative electroencephalographic subtyping of obsessive-compulsive disorder. In: Psychiatry Research. 1993 ; Vol. 50, No. 1. pp. 25-32.
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