TY - JOUR
T1 - Quantitative and qualitative antibody responses to immunization with the pneumococcal polysaccharide vaccine in HIV-infected patients after initiation of antiretroviral treatment
T2 - Results from a randomized clinical trial
AU - Rodriguez-Barradas, Maria C.
AU - Serpa, Jose A.
AU - Munjal, Iona
AU - Mendoza, Daniel
AU - Rueda, Adriana M.
AU - Mushtaq, Mahwish
AU - Pirofski, Liise Anne
N1 - Publisher Copyright:
© 2014 Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Background. Pneumococcal vaccination is recommended for human immunodeficiency virus-infected (HIV+) persons; the best timing for immunization with respect to initiation of antiretroviral therapy (ART) is unknown. Methods. Double-blind, placebo-controlled trial in HIV+ with CD4+ T cells/μL (CD4) ≥ 200 randomized to receive the 23-valent pneumococcal polysaccharide vaccine (PPV23) or placebo at enrollment, followed by placebo or PPV23, respectively, 9-12 months later (after ≥ 6 months of ART). Capsular polysaccharide-specific immunoglobin (Ig) G and IgM levels to serotypes 1, 3, 4, 6B, and 23F, and opsonophagocytic killing activity (OPA) to serotypes 6B and 23F were evaluated 1 month postvaccination. Results. One hundred seven subjects were enrolled, 72 (67.3%) were evaluable (36/group). Both groups had significant increases in pre- to 1-month postvaccination IgG levels, but negligible to IgM, and significant increases in OPA titers to serotype 6B but not to 23F. There were no significant differences between groups in serotype-specific IgM or IgG levels or OPA titers. For the combined groups, there was a significant correlation between serotype-specific IgG and OPA titers to 23F but not to 6B. There was no correlation between CD4, viral load and IgG responses. Conclusions. In HIV+ with CD4 ≥ 200, delaying PPV23 until ≥ 6 months of ART does not improve responses and may lead to missed opportunities for immunization.
AB - Background. Pneumococcal vaccination is recommended for human immunodeficiency virus-infected (HIV+) persons; the best timing for immunization with respect to initiation of antiretroviral therapy (ART) is unknown. Methods. Double-blind, placebo-controlled trial in HIV+ with CD4+ T cells/μL (CD4) ≥ 200 randomized to receive the 23-valent pneumococcal polysaccharide vaccine (PPV23) or placebo at enrollment, followed by placebo or PPV23, respectively, 9-12 months later (after ≥ 6 months of ART). Capsular polysaccharide-specific immunoglobin (Ig) G and IgM levels to serotypes 1, 3, 4, 6B, and 23F, and opsonophagocytic killing activity (OPA) to serotypes 6B and 23F were evaluated 1 month postvaccination. Results. One hundred seven subjects were enrolled, 72 (67.3%) were evaluable (36/group). Both groups had significant increases in pre- to 1-month postvaccination IgG levels, but negligible to IgM, and significant increases in OPA titers to serotype 6B but not to 23F. There were no significant differences between groups in serotype-specific IgM or IgG levels or OPA titers. For the combined groups, there was a significant correlation between serotype-specific IgG and OPA titers to 23F but not to 6B. There was no correlation between CD4, viral load and IgG responses. Conclusions. In HIV+ with CD4 ≥ 200, delaying PPV23 until ≥ 6 months of ART does not improve responses and may lead to missed opportunities for immunization.
KW - HIV
KW - antibody
KW - antiretroviral treatment
KW - pneumococcal capsular polysaccharides
KW - pneumococcal vaccine
UR - http://www.scopus.com/inward/record.url?scp=84930439837&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930439837&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiu819
DO - 10.1093/infdis/jiu819
M3 - Article
C2 - 25538270
AN - SCOPUS:84930439837
SN - 0022-1899
VL - 211
SP - 1703
EP - 1711
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 11
ER -