Quality Control: Maintaining molecular order and preventing cellular chaos

Sonya Neal; Fumiaki Ohtake; Ana Maria Cuervo; Ramanujan S. Hegde; Ursula Jakob; Michael Lazarou; Wendy V. Gilbert; Zhijian J. Chen; Sharon A. Tooze; James E. Haber; Kylie J. Walters; F. Ulrich Hartl

doi:10.1016/j.molcel.2022.04.002

Quality Control: Maintaining molecular order and preventing cellular chaos

Sonya Neal, Fumiaki Ohtake, Ana Maria Cuervo, Ramanujan S. Hegde, Ursula Jakob, Michael Lazarou, Wendy V. Gilbert, Zhijian J. Chen, Sharon A. Tooze, James E. Haber, Kylie J. Walters, F. Ulrich Hartl

Developmental & Molecular Biology

Research output: Contribution to journal › Comment/debate › peer-review

4 Scopus citations

Abstract

We asked experts from different fields—from genome maintenance and proteostasis to organelle degradation via ubiquitin and autophagy—“What does quality control mean to you?” Despite their diverse backgrounds, they converge on and discuss the importance of continuous quality control at all levels, context, communication, timing, decisions on whether to repair or remove, and the significance of dysregulated quality control in disease.

Original language	English (US)
Pages (from-to)	1390-1397
Number of pages	8
Journal	Molecular Cell
Volume	82
Issue number	8
DOIs	https://doi.org/10.1016/j.molcel.2022.04.002
State	Published - Apr 21 2022

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2022.04.002

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title = "Quality Control: Maintaining molecular order and preventing cellular chaos",

abstract = "We asked experts from different fields—from genome maintenance and proteostasis to organelle degradation via ubiquitin and autophagy—“What does quality control mean to you?” Despite their diverse backgrounds, they converge on and discuss the importance of continuous quality control at all levels, context, communication, timing, decisions on whether to repair or remove, and the significance of dysregulated quality control in disease.",

author = "Sonya Neal and Fumiaki Ohtake and Cuervo, {Ana Maria} and Hegde, {Ramanujan S.} and Ursula Jakob and Michael Lazarou and Gilbert, {Wendy V.} and Chen, {Zhijian J.} and Tooze, {Sharon A.} and Haber, {James E.} and Walters, {Kylie J.} and Hartl, {F. Ulrich}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = apr,

day = "21",

doi = "10.1016/j.molcel.2022.04.002",

language = "English (US)",

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T1 - Quality Control

T2 - Maintaining molecular order and preventing cellular chaos

AU - Neal, Sonya

AU - Ohtake, Fumiaki

AU - Cuervo, Ana Maria

AU - Hegde, Ramanujan S.

AU - Jakob, Ursula

AU - Lazarou, Michael

AU - Gilbert, Wendy V.

AU - Chen, Zhijian J.

AU - Tooze, Sharon A.

AU - Haber, James E.

AU - Walters, Kylie J.

AU - Hartl, F. Ulrich

PY - 2022/4/21

Y1 - 2022/4/21

N2 - We asked experts from different fields—from genome maintenance and proteostasis to organelle degradation via ubiquitin and autophagy—“What does quality control mean to you?” Despite their diverse backgrounds, they converge on and discuss the importance of continuous quality control at all levels, context, communication, timing, decisions on whether to repair or remove, and the significance of dysregulated quality control in disease.

AB - We asked experts from different fields—from genome maintenance and proteostasis to organelle degradation via ubiquitin and autophagy—“What does quality control mean to you?” Despite their diverse backgrounds, they converge on and discuss the importance of continuous quality control at all levels, context, communication, timing, decisions on whether to repair or remove, and the significance of dysregulated quality control in disease.

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U2 - 10.1016/j.molcel.2022.04.002

DO - 10.1016/j.molcel.2022.04.002

M3 - Comment/debate

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AN - SCOPUS:85128241267

SN - 1097-2765

VL - 82

SP - 1390

EP - 1397

JO - Molecular Cell

JF - Molecular Cell

IS - 8

ER -

Quality Control: Maintaining molecular order and preventing cellular chaos

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