TY - JOUR
T1 - Qualitative change in antibody responses of human immunodeficiency virus-infected individuals to pneumococcal capsular polysaccharide vaccination associated with highly active antiretroviral therapy
AU - Subramaniam, Krishanthi S.
AU - Segal, Robert
AU - Lyles, Robert H.
AU - Rodriguez-Barradas, Maria C.
AU - Pirofski, Liise Anne
N1 - Funding Information:
Financial support: National Institutes of Health (grants AI-35370, AI-45459, and AI-44374 to L.P.).
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Variable region gene family 3 (VH3) is the predominant immunoglobulin (Ig) gene family used in human antibodies to pneumococcal capsular polysaccharide (PPS). This study examined whether highly active anti-retroviral therapy (HAART) restores the ability of human immunodeficiency virus (HIV)-infected individuals to generate a VH3-positive response to PPS. The IgM, IgG, and VH3 (represented by antibodies expressing the determinant recognized by the monoclonal antibody D12) responses to PPS were determined for first-time recipients of a 23-valent PPS vaccine, both receiving and not receiving HAART, and second-time vaccine recipients receiving HAART. The results showed that only the individuals receiving HAART manifested a VH3-(D12)-positive response to PPS, despite a similar IgG response in each group. There was also a negative correlation between HIV load and PPS response for the groups receiving HAART. These findings suggest that HAART may influence qualitative aspects of the PPS response by restoring expression of certain VH3 genes used in the normal PPS response.
AB - Variable region gene family 3 (VH3) is the predominant immunoglobulin (Ig) gene family used in human antibodies to pneumococcal capsular polysaccharide (PPS). This study examined whether highly active anti-retroviral therapy (HAART) restores the ability of human immunodeficiency virus (HIV)-infected individuals to generate a VH3-positive response to PPS. The IgM, IgG, and VH3 (represented by antibodies expressing the determinant recognized by the monoclonal antibody D12) responses to PPS were determined for first-time recipients of a 23-valent PPS vaccine, both receiving and not receiving HAART, and second-time vaccine recipients receiving HAART. The results showed that only the individuals receiving HAART manifested a VH3-(D12)-positive response to PPS, despite a similar IgG response in each group. There was also a negative correlation between HIV load and PPS response for the groups receiving HAART. These findings suggest that HAART may influence qualitative aspects of the PPS response by restoring expression of certain VH3 genes used in the normal PPS response.
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U2 - 10.1086/368331
DO - 10.1086/368331
M3 - Article
C2 - 12599049
AN - SCOPUS:0037333265
SN - 0022-1899
VL - 187
SP - 758
EP - 768
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -