Qualitative change in antibody responses of human immunodeficiency virus-infected individuals to pneumococcal capsular polysaccharide vaccination associated with highly active antiretroviral therapy

Krishanthi S. Subramaniam, Robert Segal, Robert H. Lyles, Maria C. Rodriguez-Barradas, Liise-anne Pirofski

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Variable region gene family 3 (VH3) is the predominant immunoglobulin (Ig) gene family used in human antibodies to pneumococcal capsular polysaccharide (PPS). This study examined whether highly active anti-retroviral therapy (HAART) restores the ability of human immunodeficiency virus (HIV)-infected individuals to generate a VH3-positive response to PPS. The IgM, IgG, and VH3 (represented by antibodies expressing the determinant recognized by the monoclonal antibody D12) responses to PPS were determined for first-time recipients of a 23-valent PPS vaccine, both receiving and not receiving HAART, and second-time vaccine recipients receiving HAART. The results showed that only the individuals receiving HAART manifested a VH3-(D12)-positive response to PPS, despite a similar IgG response in each group. There was also a negative correlation between HIV load and PPS response for the groups receiving HAART. These findings suggest that HAART may influence qualitative aspects of the PPS response by restoring expression of certain VH3 genes used in the normal PPS response.

Original languageEnglish (US)
Pages (from-to)758-768
Number of pages11
JournalJournal of Infectious Diseases
Volume187
Issue number5
DOIs
StatePublished - Mar 1 2003

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Highly Active Antiretroviral Therapy
Antibody Formation
Polysaccharides
Vaccination
HIV
Therapeutics
Immunoglobulin G
Immunoglobulin Genes
Antibodies
Genes
Immunoglobulin M
Vaccines
Monoclonal Antibodies

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Qualitative change in antibody responses of human immunodeficiency virus-infected individuals to pneumococcal capsular polysaccharide vaccination associated with highly active antiretroviral therapy. / Subramaniam, Krishanthi S.; Segal, Robert; Lyles, Robert H.; Rodriguez-Barradas, Maria C.; Pirofski, Liise-anne.

In: Journal of Infectious Diseases, Vol. 187, No. 5, 01.03.2003, p. 758-768.

Research output: Contribution to journalArticle

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abstract = "Variable region gene family 3 (VH3) is the predominant immunoglobulin (Ig) gene family used in human antibodies to pneumococcal capsular polysaccharide (PPS). This study examined whether highly active anti-retroviral therapy (HAART) restores the ability of human immunodeficiency virus (HIV)-infected individuals to generate a VH3-positive response to PPS. The IgM, IgG, and VH3 (represented by antibodies expressing the determinant recognized by the monoclonal antibody D12) responses to PPS were determined for first-time recipients of a 23-valent PPS vaccine, both receiving and not receiving HAART, and second-time vaccine recipients receiving HAART. The results showed that only the individuals receiving HAART manifested a VH3-(D12)-positive response to PPS, despite a similar IgG response in each group. There was also a negative correlation between HIV load and PPS response for the groups receiving HAART. These findings suggest that HAART may influence qualitative aspects of the PPS response by restoring expression of certain VH3 genes used in the normal PPS response.",
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