Pyrophosphate interactions at the transition states of plasmodium falciparum and human orotate phosphoribosyltransferases

Medicine & Life Sciences

• Orotate Phosphoribosyltransferase 100%
• diphosphoric acid 75%
• orotidine 70%
• Isotopes 61%
• Plasmodium falciparum 59%
• Kinetics 40%
• orotidylic acid 35%
• Phosphonoacetic Acid 31%
• Diphosphates 24%
• Carbon 18%
• Catalytic Domain 17%
• Enzymes 10%

Chemical Compounds

• Orotate 87%
• Transition State 46%
• Orotidine 34%
• Kinetic Isotope Effect 23%
• Nucleophile 18%
• Transition State Structure 17%
• Phosphonoacetic Acid 11%
• Dihedral Angle 5%
• Carbon Atom 3%

Engineering & Materials Science

• Nucleophiles 87%
• Isotopes 51%
• Substrates 39%
• Dihedral angle 21%
• Enzymes 16%
• Acids 12%
• Carbon 10%
• Geometry 8%