Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi

Nanting Ni, Gaurav Choudhary, Minyong Li, Binghe Wang

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Bacteria can coordinate community-wide behaviors through quorum sensing, that is, the secretion and sensing of autoinducer (AI) molecules. Bacterial quorum sensing is implicated in the regulation of pathologically relevant events such as biofilm formation, bacterial virulence, and drug resistance. Inhibitors of bacterial quorum sensing could therefore be useful therapeutics. Herein we report for the first time the discovery of several pyrogallol compounds as single digit micromolar inhibitors of bacterial quorum sensing in Vibrio harveyi.

Original languageEnglish (US)
Pages (from-to)1567-1572
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number5
DOIs
StatePublished - Mar 1 2008
Externally publishedYes

Keywords

  • Antagonists
  • Pyrogallol
  • V. harveyi

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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