Pyridoxine megavitaminosis produces degeneration of peripheral sensory neurons (sensory neuronopathy) in the dog

G. Krinke, H. H. Schaumburg, P. S. Spencer, J. Suter, P. Thomann, R. Hess

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Pyridoxine, a water-soluble vitamin, produces a sensory neuronopathy when administered in high doses to dogs. Beagles who received a daily oral dose of 300 mg/kg or pyridoxol hydrochloride developed a swaying gait within 9 days. They eventually became unable to walk, but were not weak. Animals were sacrificed at intervals up to 78 days. Morphological examination revealed widespread neuronal degeneration in the dorsal root ganglia and the Gasserian ganglia. Cytoplasmic changes were first observed after 8 days and consisted of small, electrolucent vacuoles that subsequently coalesced leading to death of the cells. Degeneration of sensory nerve fibers in peripheral nerves, dorsal columns of the spinal cord and the descending spinal tract of the trigeminal nerve was apparent. The pathogenesis of these changes is unclear, but may, in part, reflect the selective permeability of blood vessels in the peripheral ganglia. It is apparent that the peripheral neuropathy previously attributed to pyridoxine actually represents a toxic, peripheral sensory neuronopathy.

Original languageEnglish (US)
Pages (from-to)13-24
Number of pages12
JournalNeuroToxicology
Volume2
Issue number1
StatePublished - 1981
Externally publishedYes

Fingerprint

Pyridoxine
Dogs
Trigeminal Ganglion
Trigeminal Nerve
Poisons
Blood vessels
Spinal Ganglia
Peripheral Nervous System Diseases
Vacuoles
Gait
Peripheral Nerves
Nerve Fibers
Vitamins
Ganglia
Blood Vessels
Permeability
Spinal Cord
Animals
Cell Death
Cells

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

Cite this

Krinke, G., Schaumburg, H. H., Spencer, P. S., Suter, J., Thomann, P., & Hess, R. (1981). Pyridoxine megavitaminosis produces degeneration of peripheral sensory neurons (sensory neuronopathy) in the dog. NeuroToxicology, 2(1), 13-24.

Pyridoxine megavitaminosis produces degeneration of peripheral sensory neurons (sensory neuronopathy) in the dog. / Krinke, G.; Schaumburg, H. H.; Spencer, P. S.; Suter, J.; Thomann, P.; Hess, R.

In: NeuroToxicology, Vol. 2, No. 1, 1981, p. 13-24.

Research output: Contribution to journalArticle

Krinke, G, Schaumburg, HH, Spencer, PS, Suter, J, Thomann, P & Hess, R 1981, 'Pyridoxine megavitaminosis produces degeneration of peripheral sensory neurons (sensory neuronopathy) in the dog', NeuroToxicology, vol. 2, no. 1, pp. 13-24.
Krinke G, Schaumburg HH, Spencer PS, Suter J, Thomann P, Hess R. Pyridoxine megavitaminosis produces degeneration of peripheral sensory neurons (sensory neuronopathy) in the dog. NeuroToxicology. 1981;2(1):13-24.
Krinke, G. ; Schaumburg, H. H. ; Spencer, P. S. ; Suter, J. ; Thomann, P. ; Hess, R. / Pyridoxine megavitaminosis produces degeneration of peripheral sensory neurons (sensory neuronopathy) in the dog. In: NeuroToxicology. 1981 ; Vol. 2, No. 1. pp. 13-24.
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