Pyramid power: Principal cells of the hippocampus unite!

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Electrical transmission in the mammalian brain is now well established. A new study by Thomson and colleagues elegantly demonstrates coupling between CA1 hippocampal pyramidal cells, which is far more common than previously supposed. Although the history of coupling is extensive, doubt, predjudice, and technical issues long kept it from wide acceptance. Here "spikelets" or "fast prepotentials" are found when two cells are coupled and in this situation result from electrical transmission of impulses from one coupled cell to the other. Interesting questions remain as to whether connexin or pannexin gap junctions serve as the molecular substrate of transmission, and the role of electrical transmission in hippocampal physiology is uncertain. Increased coupling could well contribute to the known tendency of the hippocampus to exhibit seizure activity.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalBrain Cell Biology
Volume35
Issue number1
DOIs
StatePublished - Feb 2006

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Hippocampus
Connexins
Pyramidal Cells
Gap Junctions
Seizures
History
Brain

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Pyramid power : Principal cells of the hippocampus unite! / Bennett, Michael V. L.; Pereda, Alberto E.

In: Brain Cell Biology, Vol. 35, No. 1, 02.2006, p. 5-11.

Research output: Contribution to journalArticle

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