PYR-41, A Ubiquitin-Activating Enzyme E1 Inhibitor, Attenuates Lung Injury in Sepsis

Medicine & Life Sciences

• 4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester 100%
• Ubiquitin-Activating Enzymes 78%
• Enzyme Inhibitors 54%
• Lung Injury 50%
• Sepsis 38%
• Punctures 21%
• Ligation 18%
• Ubiquitination 17%
• Interleukin-1 10%
• Inflammation 9%
• keratinocyte-derived chemokines 8%
• Lung 8%
• Interleukin-6 8%
• furan 8%
• Tumor Necrosis Factor-alpha 7%
• Benzoic Acid 7%
• Chemokine CXCL2 7%
• Cytokines 6%
• Multiple Organ Failure 6%
• Dimethyl Sulfoxide 5%
• Proteins 5%
• Nitric Oxide Synthase Type II 5%
• Cyclooxygenase 2 5%
• Proteasome Endopeptidase Complex 5%
• Esters 5%
• Aspartate Aminotransferases 5%
• L-Lactate Dehydrogenase 5%
• Alanine Transaminase 5%
• Wounds and Injuries 5%
• Peroxidase 5%
• Inbred C57BL Mouse 5%
• Chemokines 5%
• Caspase 3 4%
• Lipopolysaccharides 4%
• Cell Count 3%
• Macrophages 3%
• Therapeutics 2%
• Serum 2%