Puzzles, promises and a cure for ageing

Jan Vijg, Judith Campisi

Research output: Contribution to journalArticle

237 Citations (Scopus)

Abstract

Recent discoveries in the science of ageing indicate that lifespan in model organisms such as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional or pharmacological intervention. A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect.

Original languageEnglish (US)
Pages (from-to)1065-1071
Number of pages7
JournalNature
Volume454
Issue number7208
DOIs
StatePublished - Aug 28 2008

Fingerprint

Nutrigenomics
Diptera
Plastics
Yeasts
Pharmacology

ASJC Scopus subject areas

  • General

Cite this

Puzzles, promises and a cure for ageing. / Vijg, Jan; Campisi, Judith.

In: Nature, Vol. 454, No. 7208, 28.08.2008, p. 1065-1071.

Research output: Contribution to journalArticle

Vijg, J & Campisi, J 2008, 'Puzzles, promises and a cure for ageing', Nature, vol. 454, no. 7208, pp. 1065-1071. https://doi.org/10.1038/nature07216
Vijg, Jan ; Campisi, Judith. / Puzzles, promises and a cure for ageing. In: Nature. 2008 ; Vol. 454, No. 7208. pp. 1065-1071.
@article{fd52de90ec4d4134a1a27bbe79f617af,
title = "Puzzles, promises and a cure for ageing",
abstract = "Recent discoveries in the science of ageing indicate that lifespan in model organisms such as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional or pharmacological intervention. A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect.",
author = "Jan Vijg and Judith Campisi",
year = "2008",
month = "8",
day = "28",
doi = "10.1038/nature07216",
language = "English (US)",
volume = "454",
pages = "1065--1071",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7208",

}

TY - JOUR

T1 - Puzzles, promises and a cure for ageing

AU - Vijg, Jan

AU - Campisi, Judith

PY - 2008/8/28

Y1 - 2008/8/28

N2 - Recent discoveries in the science of ageing indicate that lifespan in model organisms such as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional or pharmacological intervention. A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect.

AB - Recent discoveries in the science of ageing indicate that lifespan in model organisms such as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional or pharmacological intervention. A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect.

UR - http://www.scopus.com/inward/record.url?scp=50649101095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50649101095&partnerID=8YFLogxK

U2 - 10.1038/nature07216

DO - 10.1038/nature07216

M3 - Article

C2 - 18756247

AN - SCOPUS:50649101095

VL - 454

SP - 1065

EP - 1071

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7208

ER -