Putrescine metabolism in human brain tumors

Stephen S. Goldman, Nora D. Volkow, Jonathan Brodie, Eugene S. Flamm

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The metabolism of the polyamines, putrescine, spermidine and spermine, was studied in human brain and brain tumors. Samples of brain and tumors were incubated with3H-putrescine and the amounts of labeled polyamines were measured. The amount of putrescine conversion was found to be greater in tumors that in normal brain samples. Furthermore, the metabolism of putrescine in brain tumors was related to tumor type and appeared to correlate with the degree of malignancy. The significance of these findings with regard to positron emission tomographic scanning and therapy of patients with malignant gliomas is discussed.

Original languageEnglish (US)
Pages (from-to)23-29
Number of pages7
JournalJournal of Neuro-Oncology
Volume4
Issue number1
DOIs
Publication statusPublished - Mar 1 1986
Externally publishedYes

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Keywords

  • brain tumors
  • polyamines
  • positron emission tomography
  • putrescine

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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