Putrescine metabolism in human brain tumors

Stephen S. Goldman; Nora D. Volkow; Jonathan Brodie; Eugene S. Flamm

doi:10.1007/BF02157998

Putrescine metabolism in human brain tumors

Stephen S. Goldman, Nora D. Volkow, Jonathan Brodie, Eugene S. Flamm

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The metabolism of the polyamines, putrescine, spermidine and spermine, was studied in human brain and brain tumors. Samples of brain and tumors were incubated with³H-putrescine and the amounts of labeled polyamines were measured. The amount of putrescine conversion was found to be greater in tumors that in normal brain samples. Furthermore, the metabolism of putrescine in brain tumors was related to tumor type and appeared to correlate with the degree of malignancy. The significance of these findings with regard to positron emission tomographic scanning and therapy of patients with malignant gliomas is discussed.

Original language	English (US)
Pages (from-to)	23-29
Number of pages	7
Journal	Journal of Neuro-Oncology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1007/BF02157998
State	Published - Mar 1986
Externally published	Yes

Keywords

brain tumors
polyamines
positron emission tomography
putrescine

ASJC Scopus subject areas

Oncology
Neurology
Clinical Neurology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02157998

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title = "Putrescine metabolism in human brain tumors",

abstract = "The metabolism of the polyamines, putrescine, spermidine and spermine, was studied in human brain and brain tumors. Samples of brain and tumors were incubated with3H-putrescine and the amounts of labeled polyamines were measured. The amount of putrescine conversion was found to be greater in tumors that in normal brain samples. Furthermore, the metabolism of putrescine in brain tumors was related to tumor type and appeared to correlate with the degree of malignancy. The significance of these findings with regard to positron emission tomographic scanning and therapy of patients with malignant gliomas is discussed.",

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author = "Goldman, {Stephen S.} and Volkow, {Nora D.} and Jonathan Brodie and Flamm, {Eugene S.}",

year = "1986",

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language = "English (US)",

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T1 - Putrescine metabolism in human brain tumors

AU - Goldman, Stephen S.

AU - Volkow, Nora D.

AU - Brodie, Jonathan

AU - Flamm, Eugene S.

PY - 1986/3

Y1 - 1986/3

N2 - The metabolism of the polyamines, putrescine, spermidine and spermine, was studied in human brain and brain tumors. Samples of brain and tumors were incubated with3H-putrescine and the amounts of labeled polyamines were measured. The amount of putrescine conversion was found to be greater in tumors that in normal brain samples. Furthermore, the metabolism of putrescine in brain tumors was related to tumor type and appeared to correlate with the degree of malignancy. The significance of these findings with regard to positron emission tomographic scanning and therapy of patients with malignant gliomas is discussed.

AB - The metabolism of the polyamines, putrescine, spermidine and spermine, was studied in human brain and brain tumors. Samples of brain and tumors were incubated with3H-putrescine and the amounts of labeled polyamines were measured. The amount of putrescine conversion was found to be greater in tumors that in normal brain samples. Furthermore, the metabolism of putrescine in brain tumors was related to tumor type and appeared to correlate with the degree of malignancy. The significance of these findings with regard to positron emission tomographic scanning and therapy of patients with malignant gliomas is discussed.

KW - brain tumors

KW - polyamines

KW - positron emission tomography

KW - putrescine

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JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

IS - 1

ER -

Putrescine metabolism in human brain tumors

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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