Purkinje Cells Directly Inhibit Granule Cells in Specialized Regions of the Cerebellar Cortex

Chong Guo, Laurens Witter, Stephanie Rudolph, Hunter L. Elliott, Katelin A. Ennis, Wade G. Regehr

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Inhibition of granule cells plays a key role in gating the flow of signals into the cerebellum, and it is thought that Golgi cells are the only interneurons that inhibit granule cells. Here we show that Purkinje cells, the sole output neurons of the cerebellar cortex, also directly inhibit granule cells via their axon collaterals. Anatomical and optogenetic studies indicate that this non-canonical feedback is region specific: it is most prominent in lobules that regulate eye movement and process vestibular information. Collaterals provide fast, slow, and tonic inhibition to granule cells, and thus allow Purkinje cells to regulate granule cell excitability on multiple timescales. We propose that this feedback mechanism could regulate excitability of the input layer, contribute to sparse coding, and mediate temporal integration.

Original languageEnglish (US)
Pages (from-to)1330-1341
Number of pages12
JournalNeuron
Volume91
Issue number6
DOIs
StatePublished - Sep 21 2016

ASJC Scopus subject areas

  • Neuroscience(all)

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