Pulsed magnetic fields applied to a transferred arterial loop support the rat groin composite flap

Renata V. Weber, Alberto Navarro, June K. Wu, Han Liang Yu, Berish Strauch

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Pulsed magnetic fields have been shown to stimulate neovascularization in the authors' laboratory. The rat groin composite flap was used to create a prospective randomized trial to test the effectiveness of these pulsed magnetic fields. The skin paddle to this flap is highly consistent, and the authors proposed using the flap to study how pulsed magnetic fields affect composite flap survival when the dominant vessel to the flap is divided and flap survival becomes dependent on a transferred vessel loop. Forty-three rats had the tail artery microsurgically anastomosed to the femoral artery and placed between the groin musculature and the abdominal skin. Pulsed magnetic energy of 1 gauss was applied for 8 (n = 14) or 12 (n = 8) weeks to the experimental groups. Control groups were treated in a comparable manner for 8 (n= 16) or 12 (n = 5) weeks. After the 8 or 12 weeks, all groups had an 8 × 4-cm skin flap raised, and the superficial epigastric artery, the main feeding vessel, was ligated. After 5 days, the total area of the flap and the area of necrosis were traced onto velum paper for each rat. The percent survival was calculated per rat, and a mean survival percentage was calculated per group. The experimental animals treated with pulsed magnetic fields for 8 weeks had statistically significant improved flap survival over the control animals. The study provides evidence that pulsed magnetic energy stimulates angiogenesis and suggests a possible use of this modality to create island vascular flaps in otherwise random vascular territories.

Original languageEnglish (US)
Pages (from-to)1185-1189
Number of pages5
JournalPlastic and Reconstructive Surgery
Volume114
Issue number5
DOIs
StatePublished - Oct 2004
Externally publishedYes

Fingerprint

Groin
Magnetic Fields
Skin
Blood Vessels
Epigastric Arteries
Surgical Flaps
Femoral Artery
Tail
Necrosis
Arteries
Control Groups

ASJC Scopus subject areas

  • Surgery

Cite this

Pulsed magnetic fields applied to a transferred arterial loop support the rat groin composite flap. / Weber, Renata V.; Navarro, Alberto; Wu, June K.; Yu, Han Liang; Strauch, Berish.

In: Plastic and Reconstructive Surgery, Vol. 114, No. 5, 10.2004, p. 1185-1189.

Research output: Contribution to journalArticle

Weber, Renata V. ; Navarro, Alberto ; Wu, June K. ; Yu, Han Liang ; Strauch, Berish. / Pulsed magnetic fields applied to a transferred arterial loop support the rat groin composite flap. In: Plastic and Reconstructive Surgery. 2004 ; Vol. 114, No. 5. pp. 1185-1189.
@article{bb0eb16a885b4daaac61bf920ae8efd6,
title = "Pulsed magnetic fields applied to a transferred arterial loop support the rat groin composite flap",
abstract = "Pulsed magnetic fields have been shown to stimulate neovascularization in the authors' laboratory. The rat groin composite flap was used to create a prospective randomized trial to test the effectiveness of these pulsed magnetic fields. The skin paddle to this flap is highly consistent, and the authors proposed using the flap to study how pulsed magnetic fields affect composite flap survival when the dominant vessel to the flap is divided and flap survival becomes dependent on a transferred vessel loop. Forty-three rats had the tail artery microsurgically anastomosed to the femoral artery and placed between the groin musculature and the abdominal skin. Pulsed magnetic energy of 1 gauss was applied for 8 (n = 14) or 12 (n = 8) weeks to the experimental groups. Control groups were treated in a comparable manner for 8 (n= 16) or 12 (n = 5) weeks. After the 8 or 12 weeks, all groups had an 8 × 4-cm skin flap raised, and the superficial epigastric artery, the main feeding vessel, was ligated. After 5 days, the total area of the flap and the area of necrosis were traced onto velum paper for each rat. The percent survival was calculated per rat, and a mean survival percentage was calculated per group. The experimental animals treated with pulsed magnetic fields for 8 weeks had statistically significant improved flap survival over the control animals. The study provides evidence that pulsed magnetic energy stimulates angiogenesis and suggests a possible use of this modality to create island vascular flaps in otherwise random vascular territories.",
author = "Weber, {Renata V.} and Alberto Navarro and Wu, {June K.} and Yu, {Han Liang} and Berish Strauch",
year = "2004",
month = "10",
doi = "10.1097/01.PRS.0000135857.95310.13",
language = "English (US)",
volume = "114",
pages = "1185--1189",
journal = "Plastic and Reconstructive Surgery",
issn = "0032-1052",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Pulsed magnetic fields applied to a transferred arterial loop support the rat groin composite flap

AU - Weber, Renata V.

AU - Navarro, Alberto

AU - Wu, June K.

AU - Yu, Han Liang

AU - Strauch, Berish

PY - 2004/10

Y1 - 2004/10

N2 - Pulsed magnetic fields have been shown to stimulate neovascularization in the authors' laboratory. The rat groin composite flap was used to create a prospective randomized trial to test the effectiveness of these pulsed magnetic fields. The skin paddle to this flap is highly consistent, and the authors proposed using the flap to study how pulsed magnetic fields affect composite flap survival when the dominant vessel to the flap is divided and flap survival becomes dependent on a transferred vessel loop. Forty-three rats had the tail artery microsurgically anastomosed to the femoral artery and placed between the groin musculature and the abdominal skin. Pulsed magnetic energy of 1 gauss was applied for 8 (n = 14) or 12 (n = 8) weeks to the experimental groups. Control groups were treated in a comparable manner for 8 (n= 16) or 12 (n = 5) weeks. After the 8 or 12 weeks, all groups had an 8 × 4-cm skin flap raised, and the superficial epigastric artery, the main feeding vessel, was ligated. After 5 days, the total area of the flap and the area of necrosis were traced onto velum paper for each rat. The percent survival was calculated per rat, and a mean survival percentage was calculated per group. The experimental animals treated with pulsed magnetic fields for 8 weeks had statistically significant improved flap survival over the control animals. The study provides evidence that pulsed magnetic energy stimulates angiogenesis and suggests a possible use of this modality to create island vascular flaps in otherwise random vascular territories.

AB - Pulsed magnetic fields have been shown to stimulate neovascularization in the authors' laboratory. The rat groin composite flap was used to create a prospective randomized trial to test the effectiveness of these pulsed magnetic fields. The skin paddle to this flap is highly consistent, and the authors proposed using the flap to study how pulsed magnetic fields affect composite flap survival when the dominant vessel to the flap is divided and flap survival becomes dependent on a transferred vessel loop. Forty-three rats had the tail artery microsurgically anastomosed to the femoral artery and placed between the groin musculature and the abdominal skin. Pulsed magnetic energy of 1 gauss was applied for 8 (n = 14) or 12 (n = 8) weeks to the experimental groups. Control groups were treated in a comparable manner for 8 (n= 16) or 12 (n = 5) weeks. After the 8 or 12 weeks, all groups had an 8 × 4-cm skin flap raised, and the superficial epigastric artery, the main feeding vessel, was ligated. After 5 days, the total area of the flap and the area of necrosis were traced onto velum paper for each rat. The percent survival was calculated per rat, and a mean survival percentage was calculated per group. The experimental animals treated with pulsed magnetic fields for 8 weeks had statistically significant improved flap survival over the control animals. The study provides evidence that pulsed magnetic energy stimulates angiogenesis and suggests a possible use of this modality to create island vascular flaps in otherwise random vascular territories.

UR - http://www.scopus.com/inward/record.url?scp=14044258035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14044258035&partnerID=8YFLogxK

U2 - 10.1097/01.PRS.0000135857.95310.13

DO - 10.1097/01.PRS.0000135857.95310.13

M3 - Article

VL - 114

SP - 1185

EP - 1189

JO - Plastic and Reconstructive Surgery

JF - Plastic and Reconstructive Surgery

SN - 0032-1052

IS - 5

ER -