Pulsed magnetic fields accelerate cutaneous wound healing in rats

Berish Strauch, Mitesh K. Patel, Jose A. Navarro, Max Berdichevsky, Han Liang Yu, Arthur A. Pilla

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

BACKGROUND: Previous studies of pulsed magnetic fields have reported enhanced fracture and chronic wound healing, endothelial cell growth, and angiogenesis. This study characterizes the biomechanical changes that occur when standard cutaneous wounds are exposed to radiofrequency pulsed magnetic fields with specific dosage parameters, in an attempt to determine whether return to functional tensile strength could be accelerated in wound healing. METHODS: There were two study phases and a total of 100 rats. In phase 1, wounds were exposed to a 1.0-G pulsed magnetic field signal in clinical use for wound repair for 30 minutes twice daily for 21 or 60 days. Phase 2 was a prospective, placebo-controlled, double-blind trial in which rats were treated for 30 minutes twice daily with three different low-amplitude signals (0.02 to 0.05 G), configured assuming a Ca binding transduction pathway, for 21 days. A midline, 8-cm, linear skin incision was made on the rat dorsum. Tensile strength was determined by measuring the point of rupture of the wound on a standard tensiometer loaded at 0.45 mm/second. RESULTS: The mean tensile strength of treated groups in phase 1 was 48 percent (p <0.001) greater than that of controls at 21 days; there was no significant difference at 60 days. In phase 2, the treated groups showed 18 percent (not significant), 44 percent, and 59 percent (p <0.001) increases in tensile strength over controls at 21 days. CONCLUSION: The authors successfully demonstrated that exposing wounds to pulsed magnetic fields of very specific configurations accelerated early wound healing in this animal model, as evidenced by significantly increased wound tensile strength at 21 days after wounding.

Original languageEnglish (US)
Pages (from-to)425-430
Number of pages6
JournalPlastic and Reconstructive Surgery
Volume120
Issue number2
DOIs
StatePublished - Aug 2007
Externally publishedYes

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Magnetic Fields
Tensile Strength
Wound Healing
Skin
Wounds and Injuries
Rupture
Endothelial Cells
Animal Models
Placebos
Growth

ASJC Scopus subject areas

  • Surgery

Cite this

Strauch, B., Patel, M. K., Navarro, J. A., Berdichevsky, M., Yu, H. L., & Pilla, A. A. (2007). Pulsed magnetic fields accelerate cutaneous wound healing in rats. Plastic and Reconstructive Surgery, 120(2), 425-430. https://doi.org/10.1097/01.prs.0000267700.15452.d0

Pulsed magnetic fields accelerate cutaneous wound healing in rats. / Strauch, Berish; Patel, Mitesh K.; Navarro, Jose A.; Berdichevsky, Max; Yu, Han Liang; Pilla, Arthur A.

In: Plastic and Reconstructive Surgery, Vol. 120, No. 2, 08.2007, p. 425-430.

Research output: Contribution to journalArticle

Strauch, B, Patel, MK, Navarro, JA, Berdichevsky, M, Yu, HL & Pilla, AA 2007, 'Pulsed magnetic fields accelerate cutaneous wound healing in rats', Plastic and Reconstructive Surgery, vol. 120, no. 2, pp. 425-430. https://doi.org/10.1097/01.prs.0000267700.15452.d0
Strauch, Berish ; Patel, Mitesh K. ; Navarro, Jose A. ; Berdichevsky, Max ; Yu, Han Liang ; Pilla, Arthur A. / Pulsed magnetic fields accelerate cutaneous wound healing in rats. In: Plastic and Reconstructive Surgery. 2007 ; Vol. 120, No. 2. pp. 425-430.
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