Pulsed arterial spin labeling using TurboFLASH with suppression of intravascular signal

Gaby S. Pell, David P. Lewis, Craig A. Branch

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Accurate quantification of perfusion with the ADC techniques requires the suppression of the majority of the intravascular signal. This is normally achieved with the use of diffusion gradients. The TurboFLASH sequence with its ultrashort repetition times is not readily amenable to this scheme. This report demonstrates the implementation of a modified TurboFLASH sequence for FAIR imaging. Intravascular suppression is achieved with a modified preparation period that includes a driven equilibrium Fourier transform (DEFT) combination of 90°-180°-90° hard RF pulses subsequent to the inversion delay. These pulses rotate the perfusion-prepared magnetization into the transverse plane where it can experience the suitably placed diffusion gradients before being returned to the longitudinal direction by the second 90° pulse. A value of b = 20-30 s/mm2 was thereby found to suppress the majority of the intravascular signal. For single-slice perfusion imaging, quantification is only slightly modified. The technique can be readily extended to multislice acquisition if the evolving flow signal after the DEFT preparation is considered. An advantage of the modified preparation scheme is evident in the multislice FAIR images by the preservation of the sign of the magnetization difference.

Original languageEnglish (US)
Pages (from-to)341-350
Number of pages10
JournalMagnetic Resonance in Medicine
Volume49
Issue number2
DOIs
StatePublished - Feb 1 2003

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Keywords

  • Diffusion
  • FAIR
  • FLASH
  • Perfusion
  • Quantitation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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