Pulmonary Vein Total Occlusion Following Catheter Ablation for Atrial Fibrillation. Clinical Implications After Long-Term Follow-Up

Luigi Di Biase, Tamer S. Fahmy, Oussama M. Wazni, Rong Bai, Dimpi Patel, Dhanunjaya Lakkireddy, Jennifer E. Cummings, Robert A. Schweikert, J. David Burkhardt, Claude S. Elayi, Mohamed Kanj, Lucie Popova, Subramanya Prasad, David O. Martin, Lourdes Prieto, Walid Saliba, Patrick Tchou, Mauricio Arruda, Andrea Natale

Research output: Contribution to journalArticle

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Abstract

Objectives: We present the clinical course and management outcomes of patients with total pulmonary vein occlusion (PVO). Background: Pulmonary vein occlusion is a rare complication that can develop after radiofrequency catheter ablation (RFA) of atrial fibrillation (AF). The long term follow-up data of patients diagnosed with PVO are minimal. Methods: Data from 18 patients with complete occlusion of at least one pulmonary vein (PV) were prospectively collected. All patients underwent RFA for AF using different strategies between September 1999 and May 2004. Pulmonary vein occlusion was diagnosed using computed tomography (CT) and later confirmed by angiography when intervention was warranted. Lung perfusion scans were performed on all patients before and after intervention. The percent stenoses of the veins draining each independent lung were added together to yield an average cumulative stenosis of the vascular cross-sectional area draining the affected lung (cumulative stenosis index [CSI]). Results: The patients' symptoms had a positive correlation with the CSI (r = 0.843, p < 0.05) and a negative one with the lung perfusion (r = -0.667, p < 0.05). A CSI ≥75% correlated well with low lung perfusion (<25%; r = -0.854, p < 0.01). Patients with a CSI ≥75% appeared to improve mostly when early (r = -0.497) and repeat dilation/stenting (r = 0.0765) were performed. Conclusions: Patients with single PVO are mostly asymptomatic and should undergo routine imaging. On the other hand, patients with concomitant ipsilateral PV stenosis/PVO and a CSI ≥75% require early and, when necessary, repeated pulmonary interventions for restoration of pulmonary flow and prevention of associated lung disease.

Original languageEnglish (US)
Pages (from-to)2493-2499
Number of pages7
JournalJournal of the American College of Cardiology
Volume48
Issue number12
DOIs
StatePublished - Dec 19 2006
Externally publishedYes

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Catheter Ablation
Pulmonary Veins
Atrial Fibrillation
Pathologic Constriction
Lung
Perfusion
Lung Diseases
Blood Vessels
Dilatation
Veins
Angiography
Tomography

ASJC Scopus subject areas

  • Nursing(all)

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Pulmonary Vein Total Occlusion Following Catheter Ablation for Atrial Fibrillation. Clinical Implications After Long-Term Follow-Up. / Di Biase, Luigi; Fahmy, Tamer S.; Wazni, Oussama M.; Bai, Rong; Patel, Dimpi; Lakkireddy, Dhanunjaya; Cummings, Jennifer E.; Schweikert, Robert A.; Burkhardt, J. David; Elayi, Claude S.; Kanj, Mohamed; Popova, Lucie; Prasad, Subramanya; Martin, David O.; Prieto, Lourdes; Saliba, Walid; Tchou, Patrick; Arruda, Mauricio; Natale, Andrea.

In: Journal of the American College of Cardiology, Vol. 48, No. 12, 19.12.2006, p. 2493-2499.

Research output: Contribution to journalArticle

Di Biase, L, Fahmy, TS, Wazni, OM, Bai, R, Patel, D, Lakkireddy, D, Cummings, JE, Schweikert, RA, Burkhardt, JD, Elayi, CS, Kanj, M, Popova, L, Prasad, S, Martin, DO, Prieto, L, Saliba, W, Tchou, P, Arruda, M & Natale, A 2006, 'Pulmonary Vein Total Occlusion Following Catheter Ablation for Atrial Fibrillation. Clinical Implications After Long-Term Follow-Up', Journal of the American College of Cardiology, vol. 48, no. 12, pp. 2493-2499. https://doi.org/10.1016/j.jacc.2006.08.038
Di Biase, Luigi ; Fahmy, Tamer S. ; Wazni, Oussama M. ; Bai, Rong ; Patel, Dimpi ; Lakkireddy, Dhanunjaya ; Cummings, Jennifer E. ; Schweikert, Robert A. ; Burkhardt, J. David ; Elayi, Claude S. ; Kanj, Mohamed ; Popova, Lucie ; Prasad, Subramanya ; Martin, David O. ; Prieto, Lourdes ; Saliba, Walid ; Tchou, Patrick ; Arruda, Mauricio ; Natale, Andrea. / Pulmonary Vein Total Occlusion Following Catheter Ablation for Atrial Fibrillation. Clinical Implications After Long-Term Follow-Up. In: Journal of the American College of Cardiology. 2006 ; Vol. 48, No. 12. pp. 2493-2499.
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abstract = "Objectives: We present the clinical course and management outcomes of patients with total pulmonary vein occlusion (PVO). Background: Pulmonary vein occlusion is a rare complication that can develop after radiofrequency catheter ablation (RFA) of atrial fibrillation (AF). The long term follow-up data of patients diagnosed with PVO are minimal. Methods: Data from 18 patients with complete occlusion of at least one pulmonary vein (PV) were prospectively collected. All patients underwent RFA for AF using different strategies between September 1999 and May 2004. Pulmonary vein occlusion was diagnosed using computed tomography (CT) and later confirmed by angiography when intervention was warranted. Lung perfusion scans were performed on all patients before and after intervention. The percent stenoses of the veins draining each independent lung were added together to yield an average cumulative stenosis of the vascular cross-sectional area draining the affected lung (cumulative stenosis index [CSI]). Results: The patients' symptoms had a positive correlation with the CSI (r = 0.843, p < 0.05) and a negative one with the lung perfusion (r = -0.667, p < 0.05). A CSI ≥75{\%} correlated well with low lung perfusion (<25{\%}; r = -0.854, p < 0.01). Patients with a CSI ≥75{\%} appeared to improve mostly when early (r = -0.497) and repeat dilation/stenting (r = 0.0765) were performed. Conclusions: Patients with single PVO are mostly asymptomatic and should undergo routine imaging. On the other hand, patients with concomitant ipsilateral PV stenosis/PVO and a CSI ≥75{\%} require early and, when necessary, repeated pulmonary interventions for restoration of pulmonary flow and prevention of associated lung disease.",
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T1 - Pulmonary Vein Total Occlusion Following Catheter Ablation for Atrial Fibrillation. Clinical Implications After Long-Term Follow-Up

AU - Di Biase, Luigi

AU - Fahmy, Tamer S.

AU - Wazni, Oussama M.

AU - Bai, Rong

AU - Patel, Dimpi

AU - Lakkireddy, Dhanunjaya

AU - Cummings, Jennifer E.

AU - Schweikert, Robert A.

AU - Burkhardt, J. David

AU - Elayi, Claude S.

AU - Kanj, Mohamed

AU - Popova, Lucie

AU - Prasad, Subramanya

AU - Martin, David O.

AU - Prieto, Lourdes

AU - Saliba, Walid

AU - Tchou, Patrick

AU - Arruda, Mauricio

AU - Natale, Andrea

PY - 2006/12/19

Y1 - 2006/12/19

N2 - Objectives: We present the clinical course and management outcomes of patients with total pulmonary vein occlusion (PVO). Background: Pulmonary vein occlusion is a rare complication that can develop after radiofrequency catheter ablation (RFA) of atrial fibrillation (AF). The long term follow-up data of patients diagnosed with PVO are minimal. Methods: Data from 18 patients with complete occlusion of at least one pulmonary vein (PV) were prospectively collected. All patients underwent RFA for AF using different strategies between September 1999 and May 2004. Pulmonary vein occlusion was diagnosed using computed tomography (CT) and later confirmed by angiography when intervention was warranted. Lung perfusion scans were performed on all patients before and after intervention. The percent stenoses of the veins draining each independent lung were added together to yield an average cumulative stenosis of the vascular cross-sectional area draining the affected lung (cumulative stenosis index [CSI]). Results: The patients' symptoms had a positive correlation with the CSI (r = 0.843, p < 0.05) and a negative one with the lung perfusion (r = -0.667, p < 0.05). A CSI ≥75% correlated well with low lung perfusion (<25%; r = -0.854, p < 0.01). Patients with a CSI ≥75% appeared to improve mostly when early (r = -0.497) and repeat dilation/stenting (r = 0.0765) were performed. Conclusions: Patients with single PVO are mostly asymptomatic and should undergo routine imaging. On the other hand, patients with concomitant ipsilateral PV stenosis/PVO and a CSI ≥75% require early and, when necessary, repeated pulmonary interventions for restoration of pulmonary flow and prevention of associated lung disease.

AB - Objectives: We present the clinical course and management outcomes of patients with total pulmonary vein occlusion (PVO). Background: Pulmonary vein occlusion is a rare complication that can develop after radiofrequency catheter ablation (RFA) of atrial fibrillation (AF). The long term follow-up data of patients diagnosed with PVO are minimal. Methods: Data from 18 patients with complete occlusion of at least one pulmonary vein (PV) were prospectively collected. All patients underwent RFA for AF using different strategies between September 1999 and May 2004. Pulmonary vein occlusion was diagnosed using computed tomography (CT) and later confirmed by angiography when intervention was warranted. Lung perfusion scans were performed on all patients before and after intervention. The percent stenoses of the veins draining each independent lung were added together to yield an average cumulative stenosis of the vascular cross-sectional area draining the affected lung (cumulative stenosis index [CSI]). Results: The patients' symptoms had a positive correlation with the CSI (r = 0.843, p < 0.05) and a negative one with the lung perfusion (r = -0.667, p < 0.05). A CSI ≥75% correlated well with low lung perfusion (<25%; r = -0.854, p < 0.01). Patients with a CSI ≥75% appeared to improve mostly when early (r = -0.497) and repeat dilation/stenting (r = 0.0765) were performed. Conclusions: Patients with single PVO are mostly asymptomatic and should undergo routine imaging. On the other hand, patients with concomitant ipsilateral PV stenosis/PVO and a CSI ≥75% require early and, when necessary, repeated pulmonary interventions for restoration of pulmonary flow and prevention of associated lung disease.

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