TY - JOUR
T1 - Pulmonary Vein Total Occlusion Following Catheter Ablation for Atrial Fibrillation. Clinical Implications After Long-Term Follow-Up
AU - Di Biase, Luigi
AU - Fahmy, Tamer S.
AU - Wazni, Oussama M.
AU - Bai, Rong
AU - Patel, Dimpi
AU - Lakkireddy, Dhanunjaya
AU - Cummings, Jennifer E.
AU - Schweikert, Robert A.
AU - Burkhardt, J. David
AU - Elayi, Claude S.
AU - Kanj, Mohamed
AU - Popova, Lucie
AU - Prasad, Subramanya
AU - Martin, David O.
AU - Prieto, Lourdes
AU - Saliba, Walid
AU - Tchou, Patrick
AU - Arruda, Mauricio
AU - Natale, Andrea
PY - 2006/12/19
Y1 - 2006/12/19
N2 - Objectives: We present the clinical course and management outcomes of patients with total pulmonary vein occlusion (PVO). Background: Pulmonary vein occlusion is a rare complication that can develop after radiofrequency catheter ablation (RFA) of atrial fibrillation (AF). The long term follow-up data of patients diagnosed with PVO are minimal. Methods: Data from 18 patients with complete occlusion of at least one pulmonary vein (PV) were prospectively collected. All patients underwent RFA for AF using different strategies between September 1999 and May 2004. Pulmonary vein occlusion was diagnosed using computed tomography (CT) and later confirmed by angiography when intervention was warranted. Lung perfusion scans were performed on all patients before and after intervention. The percent stenoses of the veins draining each independent lung were added together to yield an average cumulative stenosis of the vascular cross-sectional area draining the affected lung (cumulative stenosis index [CSI]). Results: The patients' symptoms had a positive correlation with the CSI (r = 0.843, p < 0.05) and a negative one with the lung perfusion (r = -0.667, p < 0.05). A CSI ≥75% correlated well with low lung perfusion (<25%; r = -0.854, p < 0.01). Patients with a CSI ≥75% appeared to improve mostly when early (r = -0.497) and repeat dilation/stenting (r = 0.0765) were performed. Conclusions: Patients with single PVO are mostly asymptomatic and should undergo routine imaging. On the other hand, patients with concomitant ipsilateral PV stenosis/PVO and a CSI ≥75% require early and, when necessary, repeated pulmonary interventions for restoration of pulmonary flow and prevention of associated lung disease.
AB - Objectives: We present the clinical course and management outcomes of patients with total pulmonary vein occlusion (PVO). Background: Pulmonary vein occlusion is a rare complication that can develop after radiofrequency catheter ablation (RFA) of atrial fibrillation (AF). The long term follow-up data of patients diagnosed with PVO are minimal. Methods: Data from 18 patients with complete occlusion of at least one pulmonary vein (PV) were prospectively collected. All patients underwent RFA for AF using different strategies between September 1999 and May 2004. Pulmonary vein occlusion was diagnosed using computed tomography (CT) and later confirmed by angiography when intervention was warranted. Lung perfusion scans were performed on all patients before and after intervention. The percent stenoses of the veins draining each independent lung were added together to yield an average cumulative stenosis of the vascular cross-sectional area draining the affected lung (cumulative stenosis index [CSI]). Results: The patients' symptoms had a positive correlation with the CSI (r = 0.843, p < 0.05) and a negative one with the lung perfusion (r = -0.667, p < 0.05). A CSI ≥75% correlated well with low lung perfusion (<25%; r = -0.854, p < 0.01). Patients with a CSI ≥75% appeared to improve mostly when early (r = -0.497) and repeat dilation/stenting (r = 0.0765) were performed. Conclusions: Patients with single PVO are mostly asymptomatic and should undergo routine imaging. On the other hand, patients with concomitant ipsilateral PV stenosis/PVO and a CSI ≥75% require early and, when necessary, repeated pulmonary interventions for restoration of pulmonary flow and prevention of associated lung disease.
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U2 - 10.1016/j.jacc.2006.08.038
DO - 10.1016/j.jacc.2006.08.038
M3 - Article
C2 - 17174188
AN - SCOPUS:33845328808
SN - 0735-1097
VL - 48
SP - 2493
EP - 2499
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 12
ER -