Pulmonary vein isolation for atrial fibrillation in the postpneumonectomy population

A feasibility, safety, and outcomes study

Arun Kanmanthareddy, Ajay Vallakati, Madhu Reddy Yeruva, Sanjay Dixit, Luigi Di Biase, Moussa Mansour, Hemant Boolani, Sampath Gunda, T. Jared Bunch, John D. Day, Jeremy N. Ruskin, Avanija Buddam, Sandeep Koripalli, Sudharani Bommana, Andrea Natale, Dhanunjaya Lakkireddy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background Pulmonary vein isolation (PVI) of the remnant pulmonary vein (PV) stumps in pneumonectomy patients has not been well characterized. Methods This is a multicenter observational study of patients with a remnant PV stump after pneumonectomy. Consecutive patients with a history of pneumonectomy and who had undergone RF ablation for drug refractory AF were identified from the AF database at the participating institutions. Results There were 15 patients in whom pneumonectomy was performed, for resection of tumors in 10, infection in 4, and bullae in 1 patient and who underwent RF ablation for AF. The mean age was 63 ± 7 years. The stumps were from the right lower PV in 5, left upper PV in 5, left lower PV in 3, and right upper PV in 2 patients. All the PV stumps were electrically active with PV potentials and 9 (60%) of them had triggered activity. PVI was performed in 14 and focal isolation in 1 patient. At 1-year follow-up, 80% were free of AF, off of antiarrhythmic medications. Conclusion PV stumps in AF patients with previous pneumonectomy are electrically active and are frequently the sites of active firing. Isolation of these PV stumps can be accomplished safely and effectively using catheter ablation with no practical concern for PV stenosis or compromising PV stump integrity.

Original languageEnglish (US)
Pages (from-to)385-389
Number of pages5
JournalJournal of Cardiovascular Electrophysiology
Volume26
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Pulmonary Veins
Feasibility Studies
Atrial Fibrillation
Outcome Assessment (Health Care)
Safety
Population
Pneumonectomy
Catheter Ablation
Blister
Multicenter Studies
Observational Studies
Catalytic Domain

Keywords

  • atrial fibrillation ablation
  • atrial fibrillation after pneumonectomy
  • catheter ablation of pulmonary vein stump
  • efficacy of isolation of pulmonary vein stump
  • pulmonary vein stump

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Pulmonary vein isolation for atrial fibrillation in the postpneumonectomy population : A feasibility, safety, and outcomes study. / Kanmanthareddy, Arun; Vallakati, Ajay; Reddy Yeruva, Madhu; Dixit, Sanjay; Di Biase, Luigi; Mansour, Moussa; Boolani, Hemant; Gunda, Sampath; Bunch, T. Jared; Day, John D.; Ruskin, Jeremy N.; Buddam, Avanija; Koripalli, Sandeep; Bommana, Sudharani; Natale, Andrea; Lakkireddy, Dhanunjaya.

In: Journal of Cardiovascular Electrophysiology, Vol. 26, No. 4, 01.04.2015, p. 385-389.

Research output: Contribution to journalArticle

Kanmanthareddy, A, Vallakati, A, Reddy Yeruva, M, Dixit, S, Di Biase, L, Mansour, M, Boolani, H, Gunda, S, Bunch, TJ, Day, JD, Ruskin, JN, Buddam, A, Koripalli, S, Bommana, S, Natale, A & Lakkireddy, D 2015, 'Pulmonary vein isolation for atrial fibrillation in the postpneumonectomy population: A feasibility, safety, and outcomes study', Journal of Cardiovascular Electrophysiology, vol. 26, no. 4, pp. 385-389. https://doi.org/10.1111/jce.12619
Kanmanthareddy, Arun ; Vallakati, Ajay ; Reddy Yeruva, Madhu ; Dixit, Sanjay ; Di Biase, Luigi ; Mansour, Moussa ; Boolani, Hemant ; Gunda, Sampath ; Bunch, T. Jared ; Day, John D. ; Ruskin, Jeremy N. ; Buddam, Avanija ; Koripalli, Sandeep ; Bommana, Sudharani ; Natale, Andrea ; Lakkireddy, Dhanunjaya. / Pulmonary vein isolation for atrial fibrillation in the postpneumonectomy population : A feasibility, safety, and outcomes study. In: Journal of Cardiovascular Electrophysiology. 2015 ; Vol. 26, No. 4. pp. 385-389.
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abstract = "Background Pulmonary vein isolation (PVI) of the remnant pulmonary vein (PV) stumps in pneumonectomy patients has not been well characterized. Methods This is a multicenter observational study of patients with a remnant PV stump after pneumonectomy. Consecutive patients with a history of pneumonectomy and who had undergone RF ablation for drug refractory AF were identified from the AF database at the participating institutions. Results There were 15 patients in whom pneumonectomy was performed, for resection of tumors in 10, infection in 4, and bullae in 1 patient and who underwent RF ablation for AF. The mean age was 63 ± 7 years. The stumps were from the right lower PV in 5, left upper PV in 5, left lower PV in 3, and right upper PV in 2 patients. All the PV stumps were electrically active with PV potentials and 9 (60{\%}) of them had triggered activity. PVI was performed in 14 and focal isolation in 1 patient. At 1-year follow-up, 80{\%} were free of AF, off of antiarrhythmic medications. Conclusion PV stumps in AF patients with previous pneumonectomy are electrically active and are frequently the sites of active firing. Isolation of these PV stumps can be accomplished safely and effectively using catheter ablation with no practical concern for PV stenosis or compromising PV stump integrity.",
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T2 - A feasibility, safety, and outcomes study

AU - Kanmanthareddy, Arun

AU - Vallakati, Ajay

AU - Reddy Yeruva, Madhu

AU - Dixit, Sanjay

AU - Di Biase, Luigi

AU - Mansour, Moussa

AU - Boolani, Hemant

AU - Gunda, Sampath

AU - Bunch, T. Jared

AU - Day, John D.

AU - Ruskin, Jeremy N.

AU - Buddam, Avanija

AU - Koripalli, Sandeep

AU - Bommana, Sudharani

AU - Natale, Andrea

AU - Lakkireddy, Dhanunjaya

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N2 - Background Pulmonary vein isolation (PVI) of the remnant pulmonary vein (PV) stumps in pneumonectomy patients has not been well characterized. Methods This is a multicenter observational study of patients with a remnant PV stump after pneumonectomy. Consecutive patients with a history of pneumonectomy and who had undergone RF ablation for drug refractory AF were identified from the AF database at the participating institutions. Results There were 15 patients in whom pneumonectomy was performed, for resection of tumors in 10, infection in 4, and bullae in 1 patient and who underwent RF ablation for AF. The mean age was 63 ± 7 years. The stumps were from the right lower PV in 5, left upper PV in 5, left lower PV in 3, and right upper PV in 2 patients. All the PV stumps were electrically active with PV potentials and 9 (60%) of them had triggered activity. PVI was performed in 14 and focal isolation in 1 patient. At 1-year follow-up, 80% were free of AF, off of antiarrhythmic medications. Conclusion PV stumps in AF patients with previous pneumonectomy are electrically active and are frequently the sites of active firing. Isolation of these PV stumps can be accomplished safely and effectively using catheter ablation with no practical concern for PV stenosis or compromising PV stump integrity.

AB - Background Pulmonary vein isolation (PVI) of the remnant pulmonary vein (PV) stumps in pneumonectomy patients has not been well characterized. Methods This is a multicenter observational study of patients with a remnant PV stump after pneumonectomy. Consecutive patients with a history of pneumonectomy and who had undergone RF ablation for drug refractory AF were identified from the AF database at the participating institutions. Results There were 15 patients in whom pneumonectomy was performed, for resection of tumors in 10, infection in 4, and bullae in 1 patient and who underwent RF ablation for AF. The mean age was 63 ± 7 years. The stumps were from the right lower PV in 5, left upper PV in 5, left lower PV in 3, and right upper PV in 2 patients. All the PV stumps were electrically active with PV potentials and 9 (60%) of them had triggered activity. PVI was performed in 14 and focal isolation in 1 patient. At 1-year follow-up, 80% were free of AF, off of antiarrhythmic medications. Conclusion PV stumps in AF patients with previous pneumonectomy are electrically active and are frequently the sites of active firing. Isolation of these PV stumps can be accomplished safely and effectively using catheter ablation with no practical concern for PV stenosis or compromising PV stump integrity.

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