Pulmonary vein antrum isolation, atrioventricular junction ablation, and antiarrhythmic drugs combined with direct current cardioversion

Survival rates at 7 years follow-up

Kai Sonne, Dimpi Patel, Prasant Mohanty, Luciana Armaganijan, Lucie Riedlbauchova, Moataz El-Ali, Luigi Di Biase, Preeti Venkatraman, Mazen Shaheen, Marketa Kozeluhova, Robert Schweikert, J. David Burkhardt, Robert Canby, Oussama Wazni, Walid Saliba, Andrea Natale

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: To report survival rates in patients treated with pulmonary vein antrum isolation (PVAI), atrioventricular junctional ablation (AVJA), and antiarrhythmic and direct current cardioversion (A + DCCV) at 7 years follow-up. Methods: From February 2002-December 2004, 1,000 consecutive patients underwent PVAI or A + DCCV or AVJA. These patients were matched in a nested case-controlled methodology. Survival rates were compared at the end of 7 years. Results: Three hundred and forty-five consecutive patients had undergone PVAI (34.5%), 157 (15.7%) consecutive patients AVJA, and 498(49.8%) A + DCCV. After matching the patients in a nested case-controlled methodology, 146 (32.3%) patients were in the PVAI group, 205 (59.4%) in the A + DCCV, and 101 (22.3%) in the AVJA. At 69 ± 27 months, 63 (13.9%) patients had died in the matched population. Three (2.1%) patients died in the PVAI group, 34 (16.5%) in the A + DCCV group, and 26 (25.7%) in the AVJA group. In multivariable analysis, treatment strategy was a significant predictor of mortality. Compared to patients with PVAI (reference group), those with A + DCCV (HR 4.9, p = 0.011) and AVJA (HR 10.6, p = 0.001) procedures had higher mortality risk. Conclusion: Compared to the other two procedures, patients with PVAI had the best survival rates at the end of 7 years. However, the observational case-control design of this study incurs the potential for confounding due to non-randomized treatment selection, and creates a major limitation in making valid generalization of the findings.

Original languageEnglish (US)
Pages (from-to)121-126
Number of pages6
JournalJournal of Interventional Cardiac Electrophysiology
Volume26
Issue number2
DOIs
StatePublished - Nov 2009
Externally publishedYes

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Electric Countershock
Pulmonary Veins
Anti-Arrhythmia Agents
Survival Rate
Mortality
Case-Control Studies

Keywords

  • Antiarrhythmic drugs (AADs)
  • Atrial fibrillation (AF)
  • Atrioventricular junction ablation (AVJA)
  • Catheter ablation
  • Direct current cardioversion (DCCV)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Medicine(all)

Cite this

Pulmonary vein antrum isolation, atrioventricular junction ablation, and antiarrhythmic drugs combined with direct current cardioversion : Survival rates at 7 years follow-up. / Sonne, Kai; Patel, Dimpi; Mohanty, Prasant; Armaganijan, Luciana; Riedlbauchova, Lucie; El-Ali, Moataz; Di Biase, Luigi; Venkatraman, Preeti; Shaheen, Mazen; Kozeluhova, Marketa; Schweikert, Robert; Burkhardt, J. David; Canby, Robert; Wazni, Oussama; Saliba, Walid; Natale, Andrea.

In: Journal of Interventional Cardiac Electrophysiology, Vol. 26, No. 2, 11.2009, p. 121-126.

Research output: Contribution to journalArticle

Sonne, K, Patel, D, Mohanty, P, Armaganijan, L, Riedlbauchova, L, El-Ali, M, Di Biase, L, Venkatraman, P, Shaheen, M, Kozeluhova, M, Schweikert, R, Burkhardt, JD, Canby, R, Wazni, O, Saliba, W & Natale, A 2009, 'Pulmonary vein antrum isolation, atrioventricular junction ablation, and antiarrhythmic drugs combined with direct current cardioversion: Survival rates at 7 years follow-up', Journal of Interventional Cardiac Electrophysiology, vol. 26, no. 2, pp. 121-126. https://doi.org/10.1007/s10840-009-9436-1
Sonne, Kai ; Patel, Dimpi ; Mohanty, Prasant ; Armaganijan, Luciana ; Riedlbauchova, Lucie ; El-Ali, Moataz ; Di Biase, Luigi ; Venkatraman, Preeti ; Shaheen, Mazen ; Kozeluhova, Marketa ; Schweikert, Robert ; Burkhardt, J. David ; Canby, Robert ; Wazni, Oussama ; Saliba, Walid ; Natale, Andrea. / Pulmonary vein antrum isolation, atrioventricular junction ablation, and antiarrhythmic drugs combined with direct current cardioversion : Survival rates at 7 years follow-up. In: Journal of Interventional Cardiac Electrophysiology. 2009 ; Vol. 26, No. 2. pp. 121-126.
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abstract = "Purpose: To report survival rates in patients treated with pulmonary vein antrum isolation (PVAI), atrioventricular junctional ablation (AVJA), and antiarrhythmic and direct current cardioversion (A + DCCV) at 7 years follow-up. Methods: From February 2002-December 2004, 1,000 consecutive patients underwent PVAI or A + DCCV or AVJA. These patients were matched in a nested case-controlled methodology. Survival rates were compared at the end of 7 years. Results: Three hundred and forty-five consecutive patients had undergone PVAI (34.5{\%}), 157 (15.7{\%}) consecutive patients AVJA, and 498(49.8{\%}) A + DCCV. After matching the patients in a nested case-controlled methodology, 146 (32.3{\%}) patients were in the PVAI group, 205 (59.4{\%}) in the A + DCCV, and 101 (22.3{\%}) in the AVJA. At 69 ± 27 months, 63 (13.9{\%}) patients had died in the matched population. Three (2.1{\%}) patients died in the PVAI group, 34 (16.5{\%}) in the A + DCCV group, and 26 (25.7{\%}) in the AVJA group. In multivariable analysis, treatment strategy was a significant predictor of mortality. Compared to patients with PVAI (reference group), those with A + DCCV (HR 4.9, p = 0.011) and AVJA (HR 10.6, p = 0.001) procedures had higher mortality risk. Conclusion: Compared to the other two procedures, patients with PVAI had the best survival rates at the end of 7 years. However, the observational case-control design of this study incurs the potential for confounding due to non-randomized treatment selection, and creates a major limitation in making valid generalization of the findings.",
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T2 - Survival rates at 7 years follow-up

AU - Sonne, Kai

AU - Patel, Dimpi

AU - Mohanty, Prasant

AU - Armaganijan, Luciana

AU - Riedlbauchova, Lucie

AU - El-Ali, Moataz

AU - Di Biase, Luigi

AU - Venkatraman, Preeti

AU - Shaheen, Mazen

AU - Kozeluhova, Marketa

AU - Schweikert, Robert

AU - Burkhardt, J. David

AU - Canby, Robert

AU - Wazni, Oussama

AU - Saliba, Walid

AU - Natale, Andrea

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N2 - Purpose: To report survival rates in patients treated with pulmonary vein antrum isolation (PVAI), atrioventricular junctional ablation (AVJA), and antiarrhythmic and direct current cardioversion (A + DCCV) at 7 years follow-up. Methods: From February 2002-December 2004, 1,000 consecutive patients underwent PVAI or A + DCCV or AVJA. These patients were matched in a nested case-controlled methodology. Survival rates were compared at the end of 7 years. Results: Three hundred and forty-five consecutive patients had undergone PVAI (34.5%), 157 (15.7%) consecutive patients AVJA, and 498(49.8%) A + DCCV. After matching the patients in a nested case-controlled methodology, 146 (32.3%) patients were in the PVAI group, 205 (59.4%) in the A + DCCV, and 101 (22.3%) in the AVJA. At 69 ± 27 months, 63 (13.9%) patients had died in the matched population. Three (2.1%) patients died in the PVAI group, 34 (16.5%) in the A + DCCV group, and 26 (25.7%) in the AVJA group. In multivariable analysis, treatment strategy was a significant predictor of mortality. Compared to patients with PVAI (reference group), those with A + DCCV (HR 4.9, p = 0.011) and AVJA (HR 10.6, p = 0.001) procedures had higher mortality risk. Conclusion: Compared to the other two procedures, patients with PVAI had the best survival rates at the end of 7 years. However, the observational case-control design of this study incurs the potential for confounding due to non-randomized treatment selection, and creates a major limitation in making valid generalization of the findings.

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KW - Atrial fibrillation (AF)

KW - Atrioventricular junction ablation (AVJA)

KW - Catheter ablation

KW - Direct current cardioversion (DCCV)

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