Pulmonary obstruction in individuals with cervical spinal cord lesions unmasked by bronchodilator administration

A. M. Spungen, Peter Vytautas Dicpinigaitis, P. L. Almenoff, W. A. Bauman

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

In subjects with spinal cord injury (SCI) a restrictive ventilatory impairment has been well described. Despite numerous studies of pulmonary function in patients with SCI, evidence of an obstructive component of respiratory dysfunction as a result of paralysis has not been observed in this population. We performed spirometry in 34 patients with cervical SCI before and after administration of an inhaled bronchodilator. Significant improvement in flow rate was demonstrated in 14 (41%) subjects. Our results suggest that transection of the cervical spine may result in obstruction to air flow, possibly due to interruption of the sympathetic innervation of the lung with resultant unopposed parasympathetic tone producing bronchoconstriction.

Original languageEnglish (US)
Pages (from-to)404-407
Number of pages4
JournalParaplegia
Volume31
Issue number6
StatePublished - 1993
Externally publishedYes

Fingerprint

Bronchodilator Agents
Spinal Cord Injuries
Lung
Bronchoconstriction
Spirometry
Paralysis
Spine
Air
Population
Cervical Cord

Keywords

  • Bronchodilator
  • Pulmonary obstruction
  • Quadriplegia
  • Spinal cord injury
  • Ventilatory impairment

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Pulmonary obstruction in individuals with cervical spinal cord lesions unmasked by bronchodilator administration. / Spungen, A. M.; Dicpinigaitis, Peter Vytautas; Almenoff, P. L.; Bauman, W. A.

In: Paraplegia, Vol. 31, No. 6, 1993, p. 404-407.

Research output: Contribution to journalArticle

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AB - In subjects with spinal cord injury (SCI) a restrictive ventilatory impairment has been well described. Despite numerous studies of pulmonary function in patients with SCI, evidence of an obstructive component of respiratory dysfunction as a result of paralysis has not been observed in this population. We performed spirometry in 34 patients with cervical SCI before and after administration of an inhaled bronchodilator. Significant improvement in flow rate was demonstrated in 14 (41%) subjects. Our results suggest that transection of the cervical spine may result in obstruction to air flow, possibly due to interruption of the sympathetic innervation of the lung with resultant unopposed parasympathetic tone producing bronchoconstriction.

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