Pulmonary obstruction in individuals with cervical spinal cord lesions unmasked by bronchodilator administration

A. M. Spungen; P. V. Dicpinigaitis; P. L. Almenoff; W. A. Bauman

doi:10.1038/sc.1993.67

Pulmonary obstruction in individuals with cervical spinal cord lesions unmasked by bronchodilator administration

A. M. Spungen, P. V. Dicpinigaitis, P. L. Almenoff, W. A. Bauman

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

In subjects with spinal cord injury (SCI) a restrictive ventilatory impairment has been well described, Despite numerous studies of pulmonary function in patients with SCI, evidence of an obstructive component of respiratory dysfunction as a result of paralysis has not been observed in this population, We performed spirometry in 34 patients with cervical SCI before and after administration of an inhaled bronchodilator, Significant improvement in flow rate was demonstrated in 14 (41%) subjects, Our results suggest that transection of the cervical spine may result in obstruction to air flow, possibly due to interruption of the sympathetic innervation of the lung with resultant unopposed parasympathetic tone producing bronchoconstriction.

Original language	English (US)
Pages (from-to)	404-407
Number of pages	4
Journal	Paraplegia
Volume	31
Issue number	6
DOIs	https://doi.org/10.1038/sc.1993.67
State	Published - Jun 1993
Externally published	Yes

Keywords

Bronchodilator
Pulmonary obstruction
Quadriplegia
Spinal cord injury
Ventilatory impairment

ASJC Scopus subject areas

Clinical Neurology

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10.1038/sc.1993.67

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title = "Pulmonary obstruction in individuals with cervical spinal cord lesions unmasked by bronchodilator administration",

abstract = "In subjects with spinal cord injury (SCI) a restrictive ventilatory impairment has been well described, Despite numerous studies of pulmonary function in patients with SCI, evidence of an obstructive component of respiratory dysfunction as a result of paralysis has not been observed in this population, We performed spirometry in 34 patients with cervical SCI before and after administration of an inhaled bronchodilator, Significant improvement in flow rate was demonstrated in 14 (41%) subjects, Our results suggest that transection of the cervical spine may result in obstruction to air flow, possibly due to interruption of the sympathetic innervation of the lung with resultant unopposed parasympathetic tone producing bronchoconstriction.",

keywords = "Bronchodilator, Pulmonary obstruction, Quadriplegia, Spinal cord injury, Ventilatory impairment",

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AU - Spungen, A. M.

AU - Dicpinigaitis, P. V.

AU - Almenoff, P. L.

AU - Bauman, W. A.

PY - 1993/6

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N2 - In subjects with spinal cord injury (SCI) a restrictive ventilatory impairment has been well described, Despite numerous studies of pulmonary function in patients with SCI, evidence of an obstructive component of respiratory dysfunction as a result of paralysis has not been observed in this population, We performed spirometry in 34 patients with cervical SCI before and after administration of an inhaled bronchodilator, Significant improvement in flow rate was demonstrated in 14 (41%) subjects, Our results suggest that transection of the cervical spine may result in obstruction to air flow, possibly due to interruption of the sympathetic innervation of the lung with resultant unopposed parasympathetic tone producing bronchoconstriction.

AB - In subjects with spinal cord injury (SCI) a restrictive ventilatory impairment has been well described, Despite numerous studies of pulmonary function in patients with SCI, evidence of an obstructive component of respiratory dysfunction as a result of paralysis has not been observed in this population, We performed spirometry in 34 patients with cervical SCI before and after administration of an inhaled bronchodilator, Significant improvement in flow rate was demonstrated in 14 (41%) subjects, Our results suggest that transection of the cervical spine may result in obstruction to air flow, possibly due to interruption of the sympathetic innervation of the lung with resultant unopposed parasympathetic tone producing bronchoconstriction.

KW - Bronchodilator

KW - Pulmonary obstruction

KW - Quadriplegia

KW - Spinal cord injury

KW - Ventilatory impairment

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Pulmonary obstruction in individuals with cervical spinal cord lesions unmasked by bronchodilator administration

Abstract

Keywords

ASJC Scopus subject areas

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