Pulmonary metastasectomy with therapeutic intent for soft-tissue sarcoma

Neel P. Chudgar, Murray F. Brennan, Rodrigo R. Munhoz, Peter R. Bucciarelli, Kay See Tan, Sandra P. D'Angelo, Manjit S. Bains, Matthew Bott, James Huang, Bernard J. Park, Valerie W. Rusch, Prasad S. Adusumilli, William D. Tap, Samuel Singer, David R. Jones

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

Objective Soft-tissue sarcoma is a heterogeneous disease that frequently includes the development of pulmonary metastases. The purpose of this study is to determine factors associated with improved survival among patients with soft-tissue sarcoma to help guide selection for pulmonary metastasectomy. Methods We reviewed a prospectively maintained database and identified 803 patients who underwent pulmonary metastasectomy for metastatic soft-tissue sarcoma between September 1991 and June 2014; of these, 539 patients undergoing 760 therapeutic-intent pulmonary metastasectomies were included. Clinicopathologic variables and characteristics of treatment were examined. The outcomes of interest were overall survival and disease-free survival. Survival was estimated with the Kaplan-Meier method and compared between variables with the log-rank test. Factors associated with hazard of death and recurrence were identified via the use of univariable and multivariable Cox proportional hazards models. Results Median overall survival was 33.2 months (95% confidence interval, 29.9-37.1), and median disease-free survival was 6.8 months (95% confidence interval, 6.0-8.0). In multivariable analyses, leiomyosarcoma histologic subtype (P =.007), primary tumor size ≤10 cm (P =.006), increasing time from primary tumor resection to development of metastases (P <.001), solitary lung metastasis (P =.001), and minimally invasive resection (P =.023) were associated with lower hazard of death. Disease-free interval ≥1 year (P =.002), and 1 pulmonary metastasis (P <.001) were associated with lower hazard of disease recurrence. Conclusions In a large single-institution study, primary tumor histologic subtype and size, numbers of pulmonary metastases, disease-free interval, and selection for minimally invasive resection are associated with increased survival in patients undergoing pulmonary metastasectomy for soft-tissue sarcoma.

Original languageEnglish (US)
Pages (from-to)319-330.e1
JournalJournal of Thoracic and Cardiovascular Surgery
Volume154
Issue number1
DOIs
StatePublished - Jul 2017
Externally publishedYes

Keywords

  • lung cancer surgery
  • metastases
  • metastatic soft-tissue sarcoma
  • pulmonary metastasectomy
  • soft-tissue sarcoma

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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