Pulmonary disease in children with acquired immune deficiency syndrome and AIDS-related complex

Arye Rubinstein, Rachel Morecki, Bernard Silverman, Morris Charytan, Ben Zion Krieger, Warren Andiman, Micha N. Ziprkowski, Harold Goldman

Research output: Contribution to journalArticle

134 Scopus citations

Abstract

Two major pulmonary diseases were defined on the basis of lung biopsies in 15 children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex. Pneumocystis carinii pneumonia was observed in eight children, and pulmonary lymphoid hyperplasia in six. One child had nonspecific interstitial pneumonitis. Children with P. carinii pneumonia had more severe hypoxemia, with higher alveolar-arterial oxygen gradients, and higher isomorphic elevations of serum lactate dehydrogenase. Clinically, children with pulmonary lymphoid hyperplasia were older, and had digital clubbing, parotid gland enlargement, and elevated serum IgG levels. Results of serologic assays and lung tissue analysis were suggestive of persistent Epstein-Barr virus infection exclusively in patients with pulmonary lymphoid hyperplasia. Recognition of the clinical and laboratory findings characteristic of each entity may assist in the differential diagnosis without the need of surgical biopsy.

Original languageEnglish (US)
Pages (from-to)498-503
Number of pages6
JournalThe Journal of Pediatrics
Volume108
Issue number4
DOIs
StatePublished - Apr 1986

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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