Pulmonary disease in children with acquired immune deficiency syndrome and AIDS-related complex

Arye Rubinstein, Rachel Morecki, Bernard A. Silverman, Morris Charytan, Ben Zion Krieger, Warren Andiman, Micha N. Ziprkowski, Harold Goldman

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Two major pulmonary diseases were defined on the basis of lung biopsies in 15 children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex. Pneumocystis carinii pneumonia was observed in eight children, and pulmonary lymphoid hyperplasia in six. One child had nonspecific interstitial pneumonitis. Children with P. carinii pneumonia had more severe hypoxemia, with higher alveolar-arterial oxygen gradients, and higher isomorphic elevations of serum lactate dehydrogenase. Clinically, children with pulmonary lymphoid hyperplasia were older, and had digital clubbing, parotid gland enlargement, and elevated serum IgG levels. Results of serologic assays and lung tissue analysis were suggestive of persistent Epstein-Barr virus infection exclusively in patients with pulmonary lymphoid hyperplasia. Recognition of the clinical and laboratory findings characteristic of each entity may assist in the differential diagnosis without the need of surgical biopsy.

Original languageEnglish (US)
Pages (from-to)498-503
Number of pages6
JournalThe Journal of Pediatrics
Volume108
Issue number4
DOIs
StatePublished - 1986

Fingerprint

Lung Diseases
Acquired Immunodeficiency Syndrome
Lung
Hyperplasia
Pneumocystis Pneumonia
Biopsy
Epstein-Barr Virus Infections
Parotid Gland
Interstitial Lung Diseases
Serum
L-Lactate Dehydrogenase
Differential Diagnosis
Immunoglobulin G
Oxygen

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Pulmonary disease in children with acquired immune deficiency syndrome and AIDS-related complex. / Rubinstein, Arye; Morecki, Rachel; Silverman, Bernard A.; Charytan, Morris; Krieger, Ben Zion; Andiman, Warren; Ziprkowski, Micha N.; Goldman, Harold.

In: The Journal of Pediatrics, Vol. 108, No. 4, 1986, p. 498-503.

Research output: Contribution to journalArticle

Rubinstein, Arye ; Morecki, Rachel ; Silverman, Bernard A. ; Charytan, Morris ; Krieger, Ben Zion ; Andiman, Warren ; Ziprkowski, Micha N. ; Goldman, Harold. / Pulmonary disease in children with acquired immune deficiency syndrome and AIDS-related complex. In: The Journal of Pediatrics. 1986 ; Vol. 108, No. 4. pp. 498-503.
@article{ba4b803cf0f94a48af6df10f0f97d75b,
title = "Pulmonary disease in children with acquired immune deficiency syndrome and AIDS-related complex",
abstract = "Two major pulmonary diseases were defined on the basis of lung biopsies in 15 children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex. Pneumocystis carinii pneumonia was observed in eight children, and pulmonary lymphoid hyperplasia in six. One child had nonspecific interstitial pneumonitis. Children with P. carinii pneumonia had more severe hypoxemia, with higher alveolar-arterial oxygen gradients, and higher isomorphic elevations of serum lactate dehydrogenase. Clinically, children with pulmonary lymphoid hyperplasia were older, and had digital clubbing, parotid gland enlargement, and elevated serum IgG levels. Results of serologic assays and lung tissue analysis were suggestive of persistent Epstein-Barr virus infection exclusively in patients with pulmonary lymphoid hyperplasia. Recognition of the clinical and laboratory findings characteristic of each entity may assist in the differential diagnosis without the need of surgical biopsy.",
author = "Arye Rubinstein and Rachel Morecki and Silverman, {Bernard A.} and Morris Charytan and Krieger, {Ben Zion} and Warren Andiman and Ziprkowski, {Micha N.} and Harold Goldman",
year = "1986",
doi = "10.1016/S0022-3476(86)80822-8",
language = "English (US)",
volume = "108",
pages = "498--503",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "4",

}

TY - JOUR

T1 - Pulmonary disease in children with acquired immune deficiency syndrome and AIDS-related complex

AU - Rubinstein, Arye

AU - Morecki, Rachel

AU - Silverman, Bernard A.

AU - Charytan, Morris

AU - Krieger, Ben Zion

AU - Andiman, Warren

AU - Ziprkowski, Micha N.

AU - Goldman, Harold

PY - 1986

Y1 - 1986

N2 - Two major pulmonary diseases were defined on the basis of lung biopsies in 15 children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex. Pneumocystis carinii pneumonia was observed in eight children, and pulmonary lymphoid hyperplasia in six. One child had nonspecific interstitial pneumonitis. Children with P. carinii pneumonia had more severe hypoxemia, with higher alveolar-arterial oxygen gradients, and higher isomorphic elevations of serum lactate dehydrogenase. Clinically, children with pulmonary lymphoid hyperplasia were older, and had digital clubbing, parotid gland enlargement, and elevated serum IgG levels. Results of serologic assays and lung tissue analysis were suggestive of persistent Epstein-Barr virus infection exclusively in patients with pulmonary lymphoid hyperplasia. Recognition of the clinical and laboratory findings characteristic of each entity may assist in the differential diagnosis without the need of surgical biopsy.

AB - Two major pulmonary diseases were defined on the basis of lung biopsies in 15 children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex. Pneumocystis carinii pneumonia was observed in eight children, and pulmonary lymphoid hyperplasia in six. One child had nonspecific interstitial pneumonitis. Children with P. carinii pneumonia had more severe hypoxemia, with higher alveolar-arterial oxygen gradients, and higher isomorphic elevations of serum lactate dehydrogenase. Clinically, children with pulmonary lymphoid hyperplasia were older, and had digital clubbing, parotid gland enlargement, and elevated serum IgG levels. Results of serologic assays and lung tissue analysis were suggestive of persistent Epstein-Barr virus infection exclusively in patients with pulmonary lymphoid hyperplasia. Recognition of the clinical and laboratory findings characteristic of each entity may assist in the differential diagnosis without the need of surgical biopsy.

UR - http://www.scopus.com/inward/record.url?scp=0022642472&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022642472&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(86)80822-8

DO - 10.1016/S0022-3476(86)80822-8

M3 - Article

VL - 108

SP - 498

EP - 503

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 4

ER -