Pulmonary biomarkers of bronchopulmonary dysplasia

Alecia M. Thompson, Vineet Bhandari

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Bronchopulmonary dysplasia, or BPD, is a chronic pulmonary disorder of premature infants, commonly defined as having an oxygen requirement at 36 weeks postmenstrual age. It is an important source of morbidity and mortality in premature neonates. Its' etiology appears to be multifactorial with the most common associations being prematurity, need for mechanical ventilation, and oxygen exposure. Implied in the pathogenesis of BPD is the role of cytokines which are immune mediators produced by most cell types. This is evidenced by studies in which there exist alterations in the levels of "pro-inflammatory" and "anti-inflammatory" cytokines. The imbalance of these cytokines have either heralded the onset or predicted the presence of BPD, or indicated a decreased propensity to developing this chronic respiratory disorder of preterm infants. Many other pulmonary markers have been shown to be altered in patients with BPD. These include markers indicative of altered lung repair processes, decreased endothelial integrity, oxidative damage and abnormal fibrinolytic activity, all of which are thought to be mechanisms contributing to the development of BPD. In this review, we will discuss the physiologic role of specific biomarkers in the pulmonary tract of the human premature neonate, the perturbations that enable them to be deranged, and their proposed association with BPD.

Original languageEnglish (US)
Pages (from-to)361-373
Number of pages13
JournalBiomarker Insights
Volume2008
Issue number3
StatePublished - 2008
Externally publishedYes

Fingerprint

Bronchopulmonary Dysplasia
Biomarkers
Cytokines
Lung
Premature Infants
Oxygen
Newborn Infant
Premature Mortality
Repair
Anti-Inflammatory Agents
Artificial Respiration
Association reactions
Morbidity

Keywords

  • Cytokins
  • Lung
  • Premature neonate

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Biochemistry, medical

Cite this

Pulmonary biomarkers of bronchopulmonary dysplasia. / Thompson, Alecia M.; Bhandari, Vineet.

In: Biomarker Insights, Vol. 2008, No. 3, 2008, p. 361-373.

Research output: Contribution to journalArticle

Thompson, AM & Bhandari, V 2008, 'Pulmonary biomarkers of bronchopulmonary dysplasia', Biomarker Insights, vol. 2008, no. 3, pp. 361-373.
Thompson, Alecia M. ; Bhandari, Vineet. / Pulmonary biomarkers of bronchopulmonary dysplasia. In: Biomarker Insights. 2008 ; Vol. 2008, No. 3. pp. 361-373.
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