TY - JOUR
T1 - Pulmonary activity on labeled leukocyte images
T2 - Physiologic, pathologic, and imaging correlation
AU - Love, Charito
AU - Opoku-Agyemang, Patrick
AU - Tomas, Maria B.
AU - Pugliese, Paul V.
AU - Bhargava, Kuldeep K.
AU - Palestro, Christopher J.
PY - 2002
Y1 - 2002
N2 - Accurate interpretation of labeled leukocyte images requires knowledge of pulmonary labeled leukocyte uptake: its prevalence and patterns and its correlation with technical, physiologic, and pathologic conditions as well as with other imaging findings. Images obtained shortly after injection of labeled cells are characterized by diffuse pulmonary activity, which decreases over time, until about 4 hours after injection when it becomes indistinguishable from background activity, remaining constant thereafter. Focal pulmonary uptake that is segmental or lobar in appearance is most often associated with bacterial pneumonia. Focal pulmonary uptake that is not segmental or lobar results from technical problems during labeling or reinfusion and is not usually associated with infection. Diffuse pulmonary uptake on images obtained more than 4 hours after reinjection of labeled cells is associated with a variety of pathologic conditions, some of the more common being opportunistic infection, radiation pneumonitis, pulmonary drug toxicity, adult respiratory distress syndrome, and sepsis. However, this pattern is almost never seen in bacterial pneumonia. When pulmonary uptake patterns are analyzed and correlated with the clinical situation, labeled leukocyte scintigraphy can provide useful information about pulmonary disease.
AB - Accurate interpretation of labeled leukocyte images requires knowledge of pulmonary labeled leukocyte uptake: its prevalence and patterns and its correlation with technical, physiologic, and pathologic conditions as well as with other imaging findings. Images obtained shortly after injection of labeled cells are characterized by diffuse pulmonary activity, which decreases over time, until about 4 hours after injection when it becomes indistinguishable from background activity, remaining constant thereafter. Focal pulmonary uptake that is segmental or lobar in appearance is most often associated with bacterial pneumonia. Focal pulmonary uptake that is not segmental or lobar results from technical problems during labeling or reinfusion and is not usually associated with infection. Diffuse pulmonary uptake on images obtained more than 4 hours after reinjection of labeled cells is associated with a variety of pathologic conditions, some of the more common being opportunistic infection, radiation pneumonitis, pulmonary drug toxicity, adult respiratory distress syndrome, and sepsis. However, this pattern is almost never seen in bacterial pneumonia. When pulmonary uptake patterns are analyzed and correlated with the clinical situation, labeled leukocyte scintigraphy can provide useful information about pulmonary disease.
KW - Lung, infection, 60.21
KW - Lung, radionuclide studies, 60.1216, 60.1217
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U2 - 10.1148/rg.226025038
DO - 10.1148/rg.226025038
M3 - Article
C2 - 12432109
AN - SCOPUS:0036830865
SN - 0271-5333
VL - 22
SP - 1385
EP - 1393
JO - Radiographics
JF - Radiographics
IS - 6
ER -