Psychosis after resection of ganglioglioma or DNET: Evidence for an association

Lisa F. Andermann, Ghislaine Savard, Heinz Joachim Meencke, Richard McLachlan, Solomon L. Moshe, Frederick Andermann

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Purpose: David Taylor and Murray Falconer suggested that some patients may develop a psychotic illness after resection of a ganglioglioma that led to intractable seizures. They implied that the mechanism of this association remained unclear. This concept is currently not universally accepted (M. Trimble, personal communication). Methods: We studied six children or young adults from four centers who developed psychosis after resection of a ganglioglioma or dysembryoplastic neuroepithelioma (DNET). Results: All patients were operated on because of intractable epilepsy. The lesions involved mainly the temporal lobe. Patients had good outcomes for seizure control. In none of the six was potentially psychogenic medication used nor were the psychotic symptoms postictal in nature. The psychosis was schizophreniform with paranoid features and prominent depressive symptoms. Although some behavioral abnormalities were described preoperatively, none had been psychotic before operation. This type of psychotic reaction was not encountered in the four centers in a comparable period after resection of other types of lesions. This complication is rare; it occurred in only one of 39 patients who had such a lesion resected. Conclusions: Psychotic illness may rarely occur after resection of a ganglioglioma or DNET for treatment of intractable epilepsy. This does not seem to occur after removal of other types of lesions. Because the patients had good outcomes for seizures, the mechanism may be related to 'forced normalization.' The original observations of Taylor and Falconer are confirmed by this study; the reasons for the selective occurrence, however, remain speculative.

Original languageEnglish (US)
Pages (from-to)83-87
Number of pages5
JournalEpilepsia
Volume40
Issue number1
DOIs
StatePublished - 1999

Fingerprint

Ganglioglioma
Psychotic Disorders
Seizures
Temporal Lobe
Young Adult
Communication
Depression

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Andermann, L. F., Savard, G., Meencke, H. J., McLachlan, R., Moshe, S. L., & Andermann, F. (1999). Psychosis after resection of ganglioglioma or DNET: Evidence for an association. Epilepsia, 40(1), 83-87. https://doi.org/10.1111/j.1528-1157.1999.tb01992.x

Psychosis after resection of ganglioglioma or DNET : Evidence for an association. / Andermann, Lisa F.; Savard, Ghislaine; Meencke, Heinz Joachim; McLachlan, Richard; Moshe, Solomon L.; Andermann, Frederick.

In: Epilepsia, Vol. 40, No. 1, 1999, p. 83-87.

Research output: Contribution to journalArticle

Andermann, LF, Savard, G, Meencke, HJ, McLachlan, R, Moshe, SL & Andermann, F 1999, 'Psychosis after resection of ganglioglioma or DNET: Evidence for an association', Epilepsia, vol. 40, no. 1, pp. 83-87. https://doi.org/10.1111/j.1528-1157.1999.tb01992.x
Andermann, Lisa F. ; Savard, Ghislaine ; Meencke, Heinz Joachim ; McLachlan, Richard ; Moshe, Solomon L. ; Andermann, Frederick. / Psychosis after resection of ganglioglioma or DNET : Evidence for an association. In: Epilepsia. 1999 ; Vol. 40, No. 1. pp. 83-87.
@article{a64df43b15354e44affe0517b9469c81,
title = "Psychosis after resection of ganglioglioma or DNET: Evidence for an association",
abstract = "Purpose: David Taylor and Murray Falconer suggested that some patients may develop a psychotic illness after resection of a ganglioglioma that led to intractable seizures. They implied that the mechanism of this association remained unclear. This concept is currently not universally accepted (M. Trimble, personal communication). Methods: We studied six children or young adults from four centers who developed psychosis after resection of a ganglioglioma or dysembryoplastic neuroepithelioma (DNET). Results: All patients were operated on because of intractable epilepsy. The lesions involved mainly the temporal lobe. Patients had good outcomes for seizure control. In none of the six was potentially psychogenic medication used nor were the psychotic symptoms postictal in nature. The psychosis was schizophreniform with paranoid features and prominent depressive symptoms. Although some behavioral abnormalities were described preoperatively, none had been psychotic before operation. This type of psychotic reaction was not encountered in the four centers in a comparable period after resection of other types of lesions. This complication is rare; it occurred in only one of 39 patients who had such a lesion resected. Conclusions: Psychotic illness may rarely occur after resection of a ganglioglioma or DNET for treatment of intractable epilepsy. This does not seem to occur after removal of other types of lesions. Because the patients had good outcomes for seizures, the mechanism may be related to 'forced normalization.' The original observations of Taylor and Falconer are confirmed by this study; the reasons for the selective occurrence, however, remain speculative.",
author = "Andermann, {Lisa F.} and Ghislaine Savard and Meencke, {Heinz Joachim} and Richard McLachlan and Moshe, {Solomon L.} and Frederick Andermann",
year = "1999",
doi = "10.1111/j.1528-1157.1999.tb01992.x",
language = "English (US)",
volume = "40",
pages = "83--87",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Psychosis after resection of ganglioglioma or DNET

T2 - Evidence for an association

AU - Andermann, Lisa F.

AU - Savard, Ghislaine

AU - Meencke, Heinz Joachim

AU - McLachlan, Richard

AU - Moshe, Solomon L.

AU - Andermann, Frederick

PY - 1999

Y1 - 1999

N2 - Purpose: David Taylor and Murray Falconer suggested that some patients may develop a psychotic illness after resection of a ganglioglioma that led to intractable seizures. They implied that the mechanism of this association remained unclear. This concept is currently not universally accepted (M. Trimble, personal communication). Methods: We studied six children or young adults from four centers who developed psychosis after resection of a ganglioglioma or dysembryoplastic neuroepithelioma (DNET). Results: All patients were operated on because of intractable epilepsy. The lesions involved mainly the temporal lobe. Patients had good outcomes for seizure control. In none of the six was potentially psychogenic medication used nor were the psychotic symptoms postictal in nature. The psychosis was schizophreniform with paranoid features and prominent depressive symptoms. Although some behavioral abnormalities were described preoperatively, none had been psychotic before operation. This type of psychotic reaction was not encountered in the four centers in a comparable period after resection of other types of lesions. This complication is rare; it occurred in only one of 39 patients who had such a lesion resected. Conclusions: Psychotic illness may rarely occur after resection of a ganglioglioma or DNET for treatment of intractable epilepsy. This does not seem to occur after removal of other types of lesions. Because the patients had good outcomes for seizures, the mechanism may be related to 'forced normalization.' The original observations of Taylor and Falconer are confirmed by this study; the reasons for the selective occurrence, however, remain speculative.

AB - Purpose: David Taylor and Murray Falconer suggested that some patients may develop a psychotic illness after resection of a ganglioglioma that led to intractable seizures. They implied that the mechanism of this association remained unclear. This concept is currently not universally accepted (M. Trimble, personal communication). Methods: We studied six children or young adults from four centers who developed psychosis after resection of a ganglioglioma or dysembryoplastic neuroepithelioma (DNET). Results: All patients were operated on because of intractable epilepsy. The lesions involved mainly the temporal lobe. Patients had good outcomes for seizure control. In none of the six was potentially psychogenic medication used nor were the psychotic symptoms postictal in nature. The psychosis was schizophreniform with paranoid features and prominent depressive symptoms. Although some behavioral abnormalities were described preoperatively, none had been psychotic before operation. This type of psychotic reaction was not encountered in the four centers in a comparable period after resection of other types of lesions. This complication is rare; it occurred in only one of 39 patients who had such a lesion resected. Conclusions: Psychotic illness may rarely occur after resection of a ganglioglioma or DNET for treatment of intractable epilepsy. This does not seem to occur after removal of other types of lesions. Because the patients had good outcomes for seizures, the mechanism may be related to 'forced normalization.' The original observations of Taylor and Falconer are confirmed by this study; the reasons for the selective occurrence, however, remain speculative.

UR - http://www.scopus.com/inward/record.url?scp=0032893317&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032893317&partnerID=8YFLogxK

U2 - 10.1111/j.1528-1157.1999.tb01992.x

DO - 10.1111/j.1528-1157.1999.tb01992.x

M3 - Article

C2 - 9924906

AN - SCOPUS:0032893317

VL - 40

SP - 83

EP - 87

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - 1

ER -