Psychiatric disturbances associated with ganciclovir therapy

Julie L. Chen, J. M. Brocavich, A. Y F Lin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: To report a case of possible ganciclovir-induced psychiatric disturbances. Case Summary: A patient with AIDS who had no known psychiatric history and mild renal dysfunction experienced exacerbation of cytomegalovirus retinitis and was treated with ganciclovir 5 mg/kg iv ql2h. The patient complained of nightmares and developed visual hallucinations and severe agitation on day 15 of ganciclovir therapy. The problems resolved after haloperidol administration and ganciclovir withdrawal and reappeared when the same regimen was reinstituted. However, the patient was able to tolerate the maintenance dose of ganciclovir at 5 mg/kg/d along with haloperidol later without further episodes of visual hallucinations. Discussion: Case reports in the literature on ganciclovir- or its analog, acyclovir-, induced psychiatric disturbances were reviewed and compared. The potential relationship between ganciclovir accumulation in patients with renal insufficiency and the observed central nervous system problems in our patient was postulated. Conclusions: It is likely that ganciclovir accumulation contributed to the acute psychotic episodes observed in our patient. Adjusting ganciclovir dosage based on the patient's renal function is probably the only approach required to prevent or reduce the incidence of these episodes.

Original languageEnglish (US)
Pages (from-to)193-195
Number of pages3
JournalAnnals of Pharmacotherapy
Volume26
Issue number2
StatePublished - 1992

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Ganciclovir
Psychiatry
Therapeutics
Hallucinations
Haloperidol
Cytomegalovirus Retinitis
Kidney
Acyclovir
Renal Insufficiency
Acquired Immunodeficiency Syndrome
Central Nervous System
Incidence

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Chen, J. L., Brocavich, J. M., & Lin, A. Y. F. (1992). Psychiatric disturbances associated with ganciclovir therapy. Annals of Pharmacotherapy, 26(2), 193-195.

Psychiatric disturbances associated with ganciclovir therapy. / Chen, Julie L.; Brocavich, J. M.; Lin, A. Y F.

In: Annals of Pharmacotherapy, Vol. 26, No. 2, 1992, p. 193-195.

Research output: Contribution to journalArticle

Chen, JL, Brocavich, JM & Lin, AYF 1992, 'Psychiatric disturbances associated with ganciclovir therapy', Annals of Pharmacotherapy, vol. 26, no. 2, pp. 193-195.
Chen, Julie L. ; Brocavich, J. M. ; Lin, A. Y F. / Psychiatric disturbances associated with ganciclovir therapy. In: Annals of Pharmacotherapy. 1992 ; Vol. 26, No. 2. pp. 193-195.
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