Psychiatric disorders in toxoplasma seropositive patients- The CD8 connection

Rajarshi Bhadra, Dustin A. Cobb, Louis M. Weiss, Imtiaz A. Khan

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Although the highest numbers of studies linking an infectious agent with schizophrenia has involved the parasite Toxoplasma gondii, the mechanistic underpinnings of this correlation has remained unaddressed. Incidentally, CD8 T cells, which play a pivotal role in mediating long-term immunity to Toxoplasma, are downregulated in schizophrenia patients. Recent studies have demonstrated that CD8 response is also impaired during chronic toxoplasmosis in murine models. In light of these new findings, in this article, we discuss the potential role of CD8 T cells in causing altered mental status in Toxoplasma seropositive schizophrenia patients.

Original languageEnglish (US)
Pages (from-to)485-489
Number of pages5
JournalSchizophrenia Bulletin
Volume39
Issue number3
DOIs
StatePublished - May 1 2013

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Keywords

  • CD8 T cells
  • PD-1
  • Toxoplasma
  • exhaustion
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

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