Psychiatric comorbidity of migraine

Sandra W. Hamelsky, Richard B. Lipton

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

Migraine affects nearly 12% of the adult population in the United States and causes significant lost productivity and decrements in health-related quality of life. The burden of migraine and the challenge in managing it are increased by the comorbid psychiatric conditions that occur in association with it. Studies in both clinical and community-based settings have demonstrated an association between migraine and a number of specific psychiatric disorders. This review will focus on the relationships between migraine and depression, generalized anxiety disorder, panic disorder, and bipolar disorder. In large scale population-based studies, persons with migraine are from 2.2 to 4.0 times more likely to have depression. In longitudinal studies, the evidence supports a bidirectional relationship between migraine and depression, with each disorder increasing the risk of the other disorder. Migraine is also comorbid with generalized anxiety disorder (Odds Ratio [OR] 3.5 to 5.3), panic disorder (OR 3.7), and bipolar disorder (OR 2.9 to 7.3). A diagnosis of migraine should lead to a heightened level of diagnostic suspicion for these comorbid psychiatric disorders. Similarly, a diagnosis of one of these psychiatric disorders should increase vigilance for migraine. Treatment plans for migraine should be mindful of the comorbid conditions.

Original languageEnglish (US)
Pages (from-to)1327-1333
Number of pages7
JournalHeadache
Volume46
Issue number9
DOIs
StatePublished - Oct 2006

Fingerprint

Migraine Disorders
Psychiatry
Comorbidity
Panic Disorder
Odds Ratio
Depression
Anxiety Disorders
Bipolar Disorder
Mental Disorders
Population
Longitudinal Studies
Quality of Life

Keywords

  • Anxiety
  • Bipolar disorder
  • Comorbidity
  • Depression
  • Migraine
  • Panic disorder

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Psychiatric comorbidity of migraine. / Hamelsky, Sandra W.; Lipton, Richard B.

In: Headache, Vol. 46, No. 9, 10.2006, p. 1327-1333.

Research output: Contribution to journalArticle

Hamelsky, Sandra W. ; Lipton, Richard B. / Psychiatric comorbidity of migraine. In: Headache. 2006 ; Vol. 46, No. 9. pp. 1327-1333.
@article{8d444470fa7d42eaa3712bb1a7264416,
title = "Psychiatric comorbidity of migraine",
abstract = "Migraine affects nearly 12{\%} of the adult population in the United States and causes significant lost productivity and decrements in health-related quality of life. The burden of migraine and the challenge in managing it are increased by the comorbid psychiatric conditions that occur in association with it. Studies in both clinical and community-based settings have demonstrated an association between migraine and a number of specific psychiatric disorders. This review will focus on the relationships between migraine and depression, generalized anxiety disorder, panic disorder, and bipolar disorder. In large scale population-based studies, persons with migraine are from 2.2 to 4.0 times more likely to have depression. In longitudinal studies, the evidence supports a bidirectional relationship between migraine and depression, with each disorder increasing the risk of the other disorder. Migraine is also comorbid with generalized anxiety disorder (Odds Ratio [OR] 3.5 to 5.3), panic disorder (OR 3.7), and bipolar disorder (OR 2.9 to 7.3). A diagnosis of migraine should lead to a heightened level of diagnostic suspicion for these comorbid psychiatric disorders. Similarly, a diagnosis of one of these psychiatric disorders should increase vigilance for migraine. Treatment plans for migraine should be mindful of the comorbid conditions.",
keywords = "Anxiety, Bipolar disorder, Comorbidity, Depression, Migraine, Panic disorder",
author = "Hamelsky, {Sandra W.} and Lipton, {Richard B.}",
year = "2006",
month = "10",
doi = "10.1111/j.1526-4610.2006.00576.x",
language = "English (US)",
volume = "46",
pages = "1327--1333",
journal = "Headache",
issn = "0017-8748",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Psychiatric comorbidity of migraine

AU - Hamelsky, Sandra W.

AU - Lipton, Richard B.

PY - 2006/10

Y1 - 2006/10

N2 - Migraine affects nearly 12% of the adult population in the United States and causes significant lost productivity and decrements in health-related quality of life. The burden of migraine and the challenge in managing it are increased by the comorbid psychiatric conditions that occur in association with it. Studies in both clinical and community-based settings have demonstrated an association between migraine and a number of specific psychiatric disorders. This review will focus on the relationships between migraine and depression, generalized anxiety disorder, panic disorder, and bipolar disorder. In large scale population-based studies, persons with migraine are from 2.2 to 4.0 times more likely to have depression. In longitudinal studies, the evidence supports a bidirectional relationship between migraine and depression, with each disorder increasing the risk of the other disorder. Migraine is also comorbid with generalized anxiety disorder (Odds Ratio [OR] 3.5 to 5.3), panic disorder (OR 3.7), and bipolar disorder (OR 2.9 to 7.3). A diagnosis of migraine should lead to a heightened level of diagnostic suspicion for these comorbid psychiatric disorders. Similarly, a diagnosis of one of these psychiatric disorders should increase vigilance for migraine. Treatment plans for migraine should be mindful of the comorbid conditions.

AB - Migraine affects nearly 12% of the adult population in the United States and causes significant lost productivity and decrements in health-related quality of life. The burden of migraine and the challenge in managing it are increased by the comorbid psychiatric conditions that occur in association with it. Studies in both clinical and community-based settings have demonstrated an association between migraine and a number of specific psychiatric disorders. This review will focus on the relationships between migraine and depression, generalized anxiety disorder, panic disorder, and bipolar disorder. In large scale population-based studies, persons with migraine are from 2.2 to 4.0 times more likely to have depression. In longitudinal studies, the evidence supports a bidirectional relationship between migraine and depression, with each disorder increasing the risk of the other disorder. Migraine is also comorbid with generalized anxiety disorder (Odds Ratio [OR] 3.5 to 5.3), panic disorder (OR 3.7), and bipolar disorder (OR 2.9 to 7.3). A diagnosis of migraine should lead to a heightened level of diagnostic suspicion for these comorbid psychiatric disorders. Similarly, a diagnosis of one of these psychiatric disorders should increase vigilance for migraine. Treatment plans for migraine should be mindful of the comorbid conditions.

KW - Anxiety

KW - Bipolar disorder

KW - Comorbidity

KW - Depression

KW - Migraine

KW - Panic disorder

UR - http://www.scopus.com/inward/record.url?scp=33749458866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749458866&partnerID=8YFLogxK

U2 - 10.1111/j.1526-4610.2006.00576.x

DO - 10.1111/j.1526-4610.2006.00576.x

M3 - Article

VL - 46

SP - 1327

EP - 1333

JO - Headache

JF - Headache

SN - 0017-8748

IS - 9

ER -