PSTPIP1 and PSTPIP2/MAYP

Violeta Chitu, E. Richard Stanley

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

PSTPIP1 and PSTPIP2 are expressed predominantly in the hematopoietic system where their C-terminal tyrosine phosphorylation is regulated by PEST family phosphatases. Both proteins deform membranes via their conserved F-BAR domains and regulate actin organization, but their actin regulatory activities differ. PSTPIPl negatively regulates actin po­ lymerization by recruiting PTP-PEST to WASP and mediating dephosphorylation o f WASP at Y291. PSTPIP2 bundles actin and increases filopodia formation. Mutations in human PSTPIPl and mouse PSTPIP2 cause autoinflammatory diseases. Analysis o f the actions o f these proteins promises to reveal novel mechanisms for the regulation o f the inflammatory response involving macrophages and osteoclasts.

Original languageEnglish (US)
Title of host publicationThe Pombe Cdc15 Homology Proteins
PublisherCRC Press
Pages49-61
Number of pages13
ISBN (Electronic)9781498712798
ISBN (Print)9781587063138
DOIs
StatePublished - Jan 1 2009

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Chitu, V., & Stanley, E. R. (2009). PSTPIP1 and PSTPIP2/MAYP. In The Pombe Cdc15 Homology Proteins (pp. 49-61). CRC Press. https://doi.org/10.1201/9781498712798-11