Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells

Michelle A. Lowes; Toyoko Kikuchi; Judilyn Fuentes-Duculan; Irma Cardinale; Lisa C. Zaba; Asifa S. Haider; Edward P. Bowman; James G. Krueger

doi:10.1038/sj.jid.5701213

Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells

Michelle A. Lowes, Toyoko Kikuchi, Judilyn Fuentes-Duculan, Irma Cardinale, Lisa C. Zaba, Asifa S. Haider, Edward P. Bowman, James G. Krueger

Research output: Contribution to journal › Article › peer-review

902 Scopus citations

Abstract

The importance of T helper 17 (Th17) cells in inflammation and autoimmunity is now being appreciated. We analyzed psoriasis skin lesions and peripheral blood for the presence of IL-17-producing T cells. We localized Th17 cells predominantly to the dermis of psoriasis skin lesions, confirmed that IL-17 mRNA increased with disease activity, and demonstrated that IL-17 mRNA expression normalized with cyclosporine therapy. IL-22 mRNA expression mirrored IL-17 and both were downregulated in parallel with keratin 16. Th17 cells are a discrete population, separate from Th1 cells (which are also in psoriasis lesions), and Th2 cells. Our findings suggest that psoriasis is a mixed Th1 and Th17 inflammatory environment. Th17 cells may be proximal regulators of psoriatic skin inflammation, and warrant further attention as therapeutic targets.

Original language	English (US)
Pages (from-to)	1207-1211
Number of pages	5
Journal	Journal of Investigative Dermatology
Volume	128
Issue number	5
DOIs	https://doi.org/10.1038/sj.jid.5701213
State	Published - May 2008
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology
Cell Biology

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title = "Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells",

abstract = "The importance of T helper 17 (Th17) cells in inflammation and autoimmunity is now being appreciated. We analyzed psoriasis skin lesions and peripheral blood for the presence of IL-17-producing T cells. We localized Th17 cells predominantly to the dermis of psoriasis skin lesions, confirmed that IL-17 mRNA increased with disease activity, and demonstrated that IL-17 mRNA expression normalized with cyclosporine therapy. IL-22 mRNA expression mirrored IL-17 and both were downregulated in parallel with keratin 16. Th17 cells are a discrete population, separate from Th1 cells (which are also in psoriasis lesions), and Th2 cells. Our findings suggest that psoriasis is a mixed Th1 and Th17 inflammatory environment. Th17 cells may be proximal regulators of psoriatic skin inflammation, and warrant further attention as therapeutic targets.",

author = "Lowes, {Michelle A.} and Toyoko Kikuchi and Judilyn Fuentes-Duculan and Irma Cardinale and Zaba, {Lisa C.} and Haider, {Asifa S.} and Bowman, {Edward P.} and Krueger, {James G.}",

note = "Funding Information: This research was supported by NIH/Clinical and Translational Science Award UL1 RR024143. MAL is supported by grant 1 K23 AR052404-01A1 and LCZ is supported by NIH MSTP grant GM07739. ",

year = "2008",

month = may,

doi = "10.1038/sj.jid.5701213",

language = "English (US)",

volume = "128",

pages = "1207--1211",

journal = "Journal of Investigative Dermatology",

issn = "0022-202X",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells

AU - Lowes, Michelle A.

AU - Kikuchi, Toyoko

AU - Fuentes-Duculan, Judilyn

AU - Cardinale, Irma

AU - Zaba, Lisa C.

AU - Haider, Asifa S.

AU - Bowman, Edward P.

AU - Krueger, James G.

N1 - Funding Information: This research was supported by NIH/Clinical and Translational Science Award UL1 RR024143. MAL is supported by grant 1 K23 AR052404-01A1 and LCZ is supported by NIH MSTP grant GM07739.

PY - 2008/5

Y1 - 2008/5

N2 - The importance of T helper 17 (Th17) cells in inflammation and autoimmunity is now being appreciated. We analyzed psoriasis skin lesions and peripheral blood for the presence of IL-17-producing T cells. We localized Th17 cells predominantly to the dermis of psoriasis skin lesions, confirmed that IL-17 mRNA increased with disease activity, and demonstrated that IL-17 mRNA expression normalized with cyclosporine therapy. IL-22 mRNA expression mirrored IL-17 and both were downregulated in parallel with keratin 16. Th17 cells are a discrete population, separate from Th1 cells (which are also in psoriasis lesions), and Th2 cells. Our findings suggest that psoriasis is a mixed Th1 and Th17 inflammatory environment. Th17 cells may be proximal regulators of psoriatic skin inflammation, and warrant further attention as therapeutic targets.

AB - The importance of T helper 17 (Th17) cells in inflammation and autoimmunity is now being appreciated. We analyzed psoriasis skin lesions and peripheral blood for the presence of IL-17-producing T cells. We localized Th17 cells predominantly to the dermis of psoriasis skin lesions, confirmed that IL-17 mRNA increased with disease activity, and demonstrated that IL-17 mRNA expression normalized with cyclosporine therapy. IL-22 mRNA expression mirrored IL-17 and both were downregulated in parallel with keratin 16. Th17 cells are a discrete population, separate from Th1 cells (which are also in psoriasis lesions), and Th2 cells. Our findings suggest that psoriasis is a mixed Th1 and Th17 inflammatory environment. Th17 cells may be proximal regulators of psoriatic skin inflammation, and warrant further attention as therapeutic targets.

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Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells

Abstract

ASJC Scopus subject areas

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