Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells

Michelle A. Lowes, Toyoko Kikuchi, Judilyn Fuentes-Duculan, Irma Cardinale, Lisa C. Zaba, Asifa S. Haider, Edward P. Bowman, James G. Krueger

Research output: Contribution to journalArticle

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Abstract

The importance of T helper 17 (Th17) cells in inflammation and autoimmunity is now being appreciated. We analyzed psoriasis skin lesions and peripheral blood for the presence of IL-17-producing T cells. We localized Th17 cells predominantly to the dermis of psoriasis skin lesions, confirmed that IL-17 mRNA increased with disease activity, and demonstrated that IL-17 mRNA expression normalized with cyclosporine therapy. IL-22 mRNA expression mirrored IL-17 and both were downregulated in parallel with keratin 16. Th17 cells are a discrete population, separate from Th1 cells (which are also in psoriasis lesions), and Th2 cells. Our findings suggest that psoriasis is a mixed Th1 and Th17 inflammatory environment. Th17 cells may be proximal regulators of psoriatic skin inflammation, and warrant further attention as therapeutic targets.

Original languageEnglish (US)
Pages (from-to)1207-1211
Number of pages5
JournalJournal of Investigative Dermatology
Volume128
Issue number5
DOIs
StatePublished - May 2008
Externally publishedYes

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Th17 Cells
T-cells
Interleukin-17
Psoriasis
Skin
Messenger RNA
Population
Keratin-16
Inflammation
Th2 Cells
Th1 Cells
Dermis
Autoimmunity
Cyclosporine
Blood
Down-Regulation
T-Lymphocytes
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

Lowes, M. A., Kikuchi, T., Fuentes-Duculan, J., Cardinale, I., Zaba, L. C., Haider, A. S., ... Krueger, J. G. (2008). Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. Journal of Investigative Dermatology, 128(5), 1207-1211. https://doi.org/10.1038/sj.jid.5701213

Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. / Lowes, Michelle A.; Kikuchi, Toyoko; Fuentes-Duculan, Judilyn; Cardinale, Irma; Zaba, Lisa C.; Haider, Asifa S.; Bowman, Edward P.; Krueger, James G.

In: Journal of Investigative Dermatology, Vol. 128, No. 5, 05.2008, p. 1207-1211.

Research output: Contribution to journalArticle

Lowes, MA, Kikuchi, T, Fuentes-Duculan, J, Cardinale, I, Zaba, LC, Haider, AS, Bowman, EP & Krueger, JG 2008, 'Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells', Journal of Investigative Dermatology, vol. 128, no. 5, pp. 1207-1211. https://doi.org/10.1038/sj.jid.5701213
Lowes MA, Kikuchi T, Fuentes-Duculan J, Cardinale I, Zaba LC, Haider AS et al. Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. Journal of Investigative Dermatology. 2008 May;128(5):1207-1211. https://doi.org/10.1038/sj.jid.5701213
Lowes, Michelle A. ; Kikuchi, Toyoko ; Fuentes-Duculan, Judilyn ; Cardinale, Irma ; Zaba, Lisa C. ; Haider, Asifa S. ; Bowman, Edward P. ; Krueger, James G. / Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. In: Journal of Investigative Dermatology. 2008 ; Vol. 128, No. 5. pp. 1207-1211.
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