Pseudogene Profiling for Cancer Subtype Classification

Yan Zhang, Deyou Zheng

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Although long thought of as “gene relics,” pseudogenes have recently gained research and medical interests because of their potential impacts on cellular pathways and of their clinical relevance. Studies have profiled pseudogenes at both DNA and RNA levels in cancers. Differences in pseudogene expression (RNA) or occurrence (DNA) help cancer subtype classification, which in turn can contribute to improving treatment selection in precision medicine. Such differences are also associated with clinical outcomes, such as patient survival. Here we review the existing methods on pseudogene profiling and discuss the application scenarios, as well as their relevant issues and challenges.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages307-317
Number of pages11
DOIs
StatePublished - 2021

Publication series

NameMethods in Molecular Biology
Volume2324
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Cancer
  • DNA and RNA profiling
  • Pseudogene
  • Subtype classification

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Fingerprint

Dive into the research topics of 'Pseudogene Profiling for Cancer Subtype Classification'. Together they form a unique fingerprint.

Cite this