Proximodistal patterning in the drosophila leg: Models and mutations

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Limbs have a proximodistal axis that usually is not apparent early in development, a striking example of epigenesis. The proximodistal axis was the subject of experimental and theoretical study before any molecular genetic understanding emerged. As developmental genetic studies in Drosophila advanced, the descriptive polar coordinate model of the 1970s evolved into an understanding of how preexisting developmental compartments interact to express signaling molecules, including Hedgehog, Wingless, and Decapentaplegic, and how these define a proximodistal axis as limbs appear.

Original languageEnglish (US)
Pages (from-to)1003-1010
Number of pages8
JournalGenetics
Volume187
Issue number4
DOIs
StatePublished - Apr 2011

Fingerprint

Drosophila
Leg
Extremities
Mutation
Hedgehogs
Molecular Biology
Theoretical Models

ASJC Scopus subject areas

  • Genetics

Cite this

Proximodistal patterning in the drosophila leg : Models and mutations. / Baker, Nicholas E.

In: Genetics, Vol. 187, No. 4, 04.2011, p. 1003-1010.

Research output: Contribution to journalArticle

@article{efd070c784b842a180378ebfe88dd91b,
title = "Proximodistal patterning in the drosophila leg: Models and mutations",
abstract = "Limbs have a proximodistal axis that usually is not apparent early in development, a striking example of epigenesis. The proximodistal axis was the subject of experimental and theoretical study before any molecular genetic understanding emerged. As developmental genetic studies in Drosophila advanced, the descriptive polar coordinate model of the 1970s evolved into an understanding of how preexisting developmental compartments interact to express signaling molecules, including Hedgehog, Wingless, and Decapentaplegic, and how these define a proximodistal axis as limbs appear.",
author = "Baker, {Nicholas E.}",
year = "2011",
month = "4",
doi = "10.1534/genetics.111.127191",
language = "English (US)",
volume = "187",
pages = "1003--1010",
journal = "Genetics",
issn = "0016-6731",
publisher = "Genetics Society of America",
number = "4",

}

TY - JOUR

T1 - Proximodistal patterning in the drosophila leg

T2 - Models and mutations

AU - Baker, Nicholas E.

PY - 2011/4

Y1 - 2011/4

N2 - Limbs have a proximodistal axis that usually is not apparent early in development, a striking example of epigenesis. The proximodistal axis was the subject of experimental and theoretical study before any molecular genetic understanding emerged. As developmental genetic studies in Drosophila advanced, the descriptive polar coordinate model of the 1970s evolved into an understanding of how preexisting developmental compartments interact to express signaling molecules, including Hedgehog, Wingless, and Decapentaplegic, and how these define a proximodistal axis as limbs appear.

AB - Limbs have a proximodistal axis that usually is not apparent early in development, a striking example of epigenesis. The proximodistal axis was the subject of experimental and theoretical study before any molecular genetic understanding emerged. As developmental genetic studies in Drosophila advanced, the descriptive polar coordinate model of the 1970s evolved into an understanding of how preexisting developmental compartments interact to express signaling molecules, including Hedgehog, Wingless, and Decapentaplegic, and how these define a proximodistal axis as limbs appear.

UR - http://www.scopus.com/inward/record.url?scp=79955450421&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955450421&partnerID=8YFLogxK

U2 - 10.1534/genetics.111.127191

DO - 10.1534/genetics.111.127191

M3 - Article

C2 - 21478472

AN - SCOPUS:79955450421

VL - 187

SP - 1003

EP - 1010

JO - Genetics

JF - Genetics

SN - 0016-6731

IS - 4

ER -