Proviral DNA of Moloney leukemia virus: Purification and visualization

A. M. Gianni; J. R. Hutton; D. Smotkin; R. A. Weinberg

doi:10.1126/science.1251192

Proviral DNA of Moloney leukemia virus: Purification and visualization

A. M. Gianni, J. R. Hutton, D. Smotkin, R. A. Weinberg

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13 Scopus citations

Abstract

Closed-circular proviral DNA of Moloney leukemia virus has been purified from a 10⁷ excess of cellular and mitochondrial DNA. The DNA can be visualized in the electron microscope and has the contour length of a molecule with a molecular weight of about 5.5 × 10⁶. Electron microscopic observation of a hybrid between viral RNA and this circular DNA confirms the viral origin of this molecule.

Original language	English (US)
Pages (from-to)	569-571
Number of pages	3
Journal	Science
Volume	191
Issue number	4227
DOIs	https://doi.org/10.1126/science.1251192
State	Published - 1976
Externally published	Yes

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title = "Proviral DNA of Moloney leukemia virus: Purification and visualization",

abstract = "Closed-circular proviral DNA of Moloney leukemia virus has been purified from a 107 excess of cellular and mitochondrial DNA. The DNA can be visualized in the electron microscope and has the contour length of a molecule with a molecular weight of about 5.5 × 106. Electron microscopic observation of a hybrid between viral RNA and this circular DNA confirms the viral origin of this molecule.",

author = "Gianni, {A. M.} and Hutton, {J. R.} and D. Smotkin and Weinberg, {R. A.}",

year = "1976",

doi = "10.1126/science.1251192",

language = "English (US)",

volume = "191",

pages = "569--571",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

number = "4227",

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T1 - Proviral DNA of Moloney leukemia virus

T2 - Purification and visualization

AU - Gianni, A. M.

AU - Hutton, J. R.

AU - Smotkin, D.

AU - Weinberg, R. A.

PY - 1976

Y1 - 1976

N2 - Closed-circular proviral DNA of Moloney leukemia virus has been purified from a 107 excess of cellular and mitochondrial DNA. The DNA can be visualized in the electron microscope and has the contour length of a molecule with a molecular weight of about 5.5 × 106. Electron microscopic observation of a hybrid between viral RNA and this circular DNA confirms the viral origin of this molecule.

AB - Closed-circular proviral DNA of Moloney leukemia virus has been purified from a 107 excess of cellular and mitochondrial DNA. The DNA can be visualized in the electron microscope and has the contour length of a molecule with a molecular weight of about 5.5 × 106. Electron microscopic observation of a hybrid between viral RNA and this circular DNA confirms the viral origin of this molecule.

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DO - 10.1126/science.1251192

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Proviral DNA of Moloney leukemia virus: Purification and visualization

Abstract

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