Proviral DNA of Moloney leukemia virus: Purification and visualization

A. M. Gianni, J. R. Hutton, D. Smotkin, R. A. Weinberg

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Closed-circular proviral DNA of Moloney leukemia virus has been purified from a 107 excess of cellular and mitochondrial DNA. The DNA can be visualized in the electron microscope and has the contour length of a molecule with a molecular weight of about 5.5 × 106. Electron microscopic observation of a hybrid between viral RNA and this circular DNA confirms the viral origin of this molecule.

Original languageEnglish (US)
Pages (from-to)569-571
Number of pages3
JournalScience
Volume191
Issue number4227
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • General

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