TY - JOUR
T1 - Prototype Quantitative Assay for Fibrinogen/Fibrin Degradation Products
T2 - Clinical Evaluation
AU - Sigal, Samuel Harold
AU - Cembrowski, George S.
AU - Shattil, Sanford J.
AU - Brown, Nancy M.
AU - Schifreen, Richard S.
AU - Schwartz, Mark W.
PY - 1987/10
Y1 - 1987/10
N2 - A new quantitative assay for fibrinogen/fibrin degradation products (FDPs) was clinically evaluated in 123 tertiary-care patients for whom the standard semiquantitative FDP assay had previously been ordered. On the basis of a comprehensive chart review, 24 patients were categorized as having disseminated intravascular coagulation (DIC), 84 were considered not to have had DIC, ten had fibrinolysis (nine of ten streptokinase induced), and five had a complicated coagulopathy whose exact nature could not be determined. The quantitative and semiquantitative FDP values were significantly correlated. However, the FDP level indicative of DIC was lower by the quantitative assay than by the semiquantitative assay, approximately 18 mg/L vs 40 mg/L, respectively. The advantages of the quantitative over the semiquantitative assay included improved precision and ability to closely monitor changes in the severity of the coagulopathy.
AB - A new quantitative assay for fibrinogen/fibrin degradation products (FDPs) was clinically evaluated in 123 tertiary-care patients for whom the standard semiquantitative FDP assay had previously been ordered. On the basis of a comprehensive chart review, 24 patients were categorized as having disseminated intravascular coagulation (DIC), 84 were considered not to have had DIC, ten had fibrinolysis (nine of ten streptokinase induced), and five had a complicated coagulopathy whose exact nature could not be determined. The quantitative and semiquantitative FDP values were significantly correlated. However, the FDP level indicative of DIC was lower by the quantitative assay than by the semiquantitative assay, approximately 18 mg/L vs 40 mg/L, respectively. The advantages of the quantitative over the semiquantitative assay included improved precision and ability to closely monitor changes in the severity of the coagulopathy.
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U2 - 10.1001/archinte.1987.00370100104017
DO - 10.1001/archinte.1987.00370100104017
M3 - Article
C2 - 3662708
AN - SCOPUS:0023194289
SN - 0003-9926
VL - 147
SP - 1790
EP - 1793
JO - Archives of internal medicine
JF - Archives of internal medicine
IS - 10
ER -