Proton MR spectroscopy of tumefactive demyelinating lesions

Amit M. Saindane, Soonmee Cha, Meng Law, Xiaonan (Nan) Xue, Edmond A. Knopp, David Zagzag

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Tumefactive demyelinating lesions (TDLs) can simulate intracranial neoplasms in clinical presentation and MR imaging appearance, and surgical biopsy is often performed in suspected tumors. Proton MR spectroscopy has been applied in assessing various intracranial diseases and is increasingly used in diagnosis and clinical management. Our purpose was to determine if multivoxel proton MR spectroscopy can be used to differentiate TDLs and high-grade gliomas. METHODS: Conventional MR images, proton MR spectra, and medical records were retrospectively reviewed in six patients with TDLs diagnosed by means of biopsy or by documented clinical improvement, with or without supporting laboratory testing and follow-up imaging. Proton MR spectra of 10 high-grade gliomas with similar conventional MR imaging appearances were used for comparison. In contrast-enhancing, central, and perilesional areas of each lesion, peak heights of N-acetylaspartate (NAA), choline (Cho), and creatine (Cr) were measured and the lactate peak noted. Cho/Cr and NAA/Cr ratios of corresponding regions in TDLs and gliomas were compared. RESULTS: No significant differences in mean Cho/Cr ratios were found in the corresponding contrast-enhancing, central, or perilesional areas of TDLs and gliomas. The mean central-region NAA/Cr ratio in gliomas was significantly lower than that of TDLs, but mean NAA/Cr ratios in other regions were not significantly different. A lactate peak was identified in four of six TDLs and three of 10 gliomas. CONCLUSION: In the cases examined, the NAA/Cr ratio in the central region of TDLs and high-grade gliomas differed significantly. However, overall metabolite profiles of both lesions were similar; this finding emphasizes the need for the cautious interpretation of spectroscopic findings.

Original languageEnglish (US)
Pages (from-to)1378-1386
Number of pages9
JournalAmerican Journal of Neuroradiology
Volume23
Issue number8
StatePublished - Sep 2002
Externally publishedYes

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Creatine
Glioma
Protons
Magnetic Resonance Spectroscopy
Choline
Lactic Acid
Biopsy
Brain Neoplasms
Medical Records
N-acetylaspartate
Neoplasms

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Saindane, A. M., Cha, S., Law, M., Xue, X. N., Knopp, E. A., & Zagzag, D. (2002). Proton MR spectroscopy of tumefactive demyelinating lesions. American Journal of Neuroradiology, 23(8), 1378-1386.

Proton MR spectroscopy of tumefactive demyelinating lesions. / Saindane, Amit M.; Cha, Soonmee; Law, Meng; Xue, Xiaonan (Nan); Knopp, Edmond A.; Zagzag, David.

In: American Journal of Neuroradiology, Vol. 23, No. 8, 09.2002, p. 1378-1386.

Research output: Contribution to journalArticle

Saindane, AM, Cha, S, Law, M, Xue, XN, Knopp, EA & Zagzag, D 2002, 'Proton MR spectroscopy of tumefactive demyelinating lesions', American Journal of Neuroradiology, vol. 23, no. 8, pp. 1378-1386.
Saindane AM, Cha S, Law M, Xue XN, Knopp EA, Zagzag D. Proton MR spectroscopy of tumefactive demyelinating lesions. American Journal of Neuroradiology. 2002 Sep;23(8):1378-1386.
Saindane, Amit M. ; Cha, Soonmee ; Law, Meng ; Xue, Xiaonan (Nan) ; Knopp, Edmond A. ; Zagzag, David. / Proton MR spectroscopy of tumefactive demyelinating lesions. In: American Journal of Neuroradiology. 2002 ; Vol. 23, No. 8. pp. 1378-1386.
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AU - Knopp, Edmond A.

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