@inbook{a9493c80d261406cac04c17ede7c4342,
title = "Protocols for Mitochondria as the Target of Pharmacological Therapy in the Context of Nonalcoholic Fatty Liver Disease (NAFLD)",
abstract = "Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent metabolic chronic liver diseases in developed countries and puts the populations at risk of progression to liver necro-inflammation, fibrosis, cirrhosis, and hepatocellular carcinoma. Mitochondrial dysfunction is involved in the onset of NAFLD and contributes to the progression from NAFLD to nonalcoholic steatohepatitis (NASH). Thus, liver mitochondria could become the target for treatments for improving liver function in NAFLD patients. This chapter describes the most important steps used for potential therapeutic interventions in NAFLD patients, discusses current options gathered from both experimental and clinical evidence, and presents some novel options for potentially improving mitochondrial function in NAFLD.",
keywords = "Fatty liver, Mitochondria, Nitrosative stress, Nonalcoholic fatty liver disease, Oxidative stress",
author = "Ignazio Grattagliano and {Di Ciaula}, Agostino and Jacek Baj and Emilio Molina-Molina and Harshitha Shanmugam and Gabriella Garruti and Wang, {David Q.H.} and Piero Portincasa",
note = "Publisher Copyright: {\textcopyright} 2021, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2021",
doi = "10.1007/978-1-0716-1433-4_12",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "201--246",
booktitle = "Methods in Molecular Biology",
}