Protein homeostasis and aging: Taking care of proteins from the cradle to the grave

Richard I. Morimoto, Ana M. Cuervo

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

All cells count on precise mechanisms that regulate protein homeostasis to maintain a stable and functional proteome. Alterations in these fine-tuned mechanisms underlie the pathogenesis of severe human diseases including, among others, common neurodegenerative disorders such as Alzheimer's or Parkinson's disease. A progressive deterioration in the ability of cells to preserve the stability of their proteome occurs with age, even in the absence of disease, and it likely contributes to different aspects of "normal" aging. A group of experts in different aspects of the biology of aging met recently to discuss the implications of altered protein homeostasis in aging, the current gaps in our understanding of the mechanisms responsible for proteome maintenance, and future opportunities for discovery in this area. We summarize here some of the key topics and main outcomes of the discussions.

Original languageEnglish (US)
Pages (from-to)167-170
Number of pages4
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume64
Issue number2
DOIs
StatePublished - Feb 2009

Keywords

  • Cellular homeostasis
  • Chaperones
  • Proteases
  • Protein degradation
  • Protein folding
  • Proteotoxicity

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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