Protein degradation and aging

Marta Martinez-Vicente, Guy Sovak, Ana Maria Cuervo

Research output: Contribution to journalArticle

177 Citations (Scopus)

Abstract

Continuous turnover of intracellular proteins is essential for the maintenance of cellular homeostasis and for the regulation of multiple cellular functions. The first reports showing a decrease in total rates of protein degradation with age are dated more than 50 years ago, when the major players in protein degradation where still to be discovered. The current advances in the molecular characterization of the two main intracellular proteolytic systems, the lysosomal and the ubiquitin proteasome system, offer now the possibility of a systematic search for the defect(s) that lead to the declined activity of these systems in old organisms. We discuss here, in light of the current findings, how malfunctioning of these two proteolytic systems can contribute to different aspects of the phenotype of aging and to the pathogenesis of some age-related diseases.

Original languageEnglish (US)
Pages (from-to)622-633
Number of pages12
JournalExperimental Gerontology
Volume40
Issue number8-9
DOIs
StatePublished - Aug 2005

Fingerprint

Proteolysis
Aging of materials
Degradation
Proteasome Endopeptidase Complex
Ubiquitin
Proteins
Homeostasis
Maintenance
Phenotype
Defects

Keywords

  • Autophagy
  • Lysosomes
  • Proteases
  • Proteasome
  • Proteolysis
  • Ubiquitin

ASJC Scopus subject areas

  • Aging
  • Medicine(all)

Cite this

Protein degradation and aging. / Martinez-Vicente, Marta; Sovak, Guy; Cuervo, Ana Maria.

In: Experimental Gerontology, Vol. 40, No. 8-9, 08.2005, p. 622-633.

Research output: Contribution to journalArticle

Martinez-Vicente, M, Sovak, G & Cuervo, AM 2005, 'Protein degradation and aging', Experimental Gerontology, vol. 40, no. 8-9, pp. 622-633. https://doi.org/10.1016/j.exger.2005.07.005
Martinez-Vicente, Marta ; Sovak, Guy ; Cuervo, Ana Maria. / Protein degradation and aging. In: Experimental Gerontology. 2005 ; Vol. 40, No. 8-9. pp. 622-633.
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