Protein degradation, aggregation, and misfolding

Ana Maria Cuervo, Esther S P Wong, Marta Martinez-Vicente

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

The cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular proteolytic systems, the main components of the cellular quality control system, contribute to neurodegeneration, with special emphasis on Parkinson's disease.

Original languageEnglish (US)
JournalMovement Disorders
Volume25
Issue numberSUPPL. 1
DOIs
StatePublished - 2010

Fingerprint

Cellular Structures
Neurodegenerative Diseases
Quality Control
Proteolysis
Parkinson Disease
Neurons

Keywords

  • Autophagy
  • Lysosomes
  • Neurodegeneration
  • Proteases
  • Protein aggregates

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Protein degradation, aggregation, and misfolding. / Cuervo, Ana Maria; Wong, Esther S P; Martinez-Vicente, Marta.

In: Movement Disorders, Vol. 25, No. SUPPL. 1, 2010.

Research output: Contribution to journalArticle

Cuervo, Ana Maria ; Wong, Esther S P ; Martinez-Vicente, Marta. / Protein degradation, aggregation, and misfolding. In: Movement Disorders. 2010 ; Vol. 25, No. SUPPL. 1.
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