Protein degradation, aggregation, and misfolding

Ana Maria Cuervo, Esther S.P. Wong, Marta Martinez-Vicente

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

The cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular proteolytic systems, the main components of the cellular quality control system, contribute to neurodegeneration, with special emphasis on Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)S49-S54
JournalMovement Disorders
Volume25
Issue numberSUPPL. 1
DOIs
StatePublished - Dec 20 2010

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Keywords

  • Autophagy
  • Lysosomes
  • Neurodegeneration
  • Proteases
  • Protein aggregates

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Cuervo, A. M., Wong, E. S. P., & Martinez-Vicente, M. (2010). Protein degradation, aggregation, and misfolding. Movement Disorders, 25(SUPPL. 1), S49-S54. https://doi.org/10.1002/mds.22718